1309199-94-7
Chemical Structure
CHVB-066
- CAS No.: 1309199-94-7
- Formula:C19H25N5O
- Molecular Weight:339.43
InChIKey: XUTHADFUJNEXCM-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=NC(NCC)=NC(C)=C2)C3=CC=C(C)C=C3
Biological Activity: CHVB-066 is an alphavirus non-structural protein nsP1 inhibitor that exhibits varying degrees of inhibitory activity against nsP1 of CHIKV and VEEV. CHVB-066 inhibits MTase and GTase activities and disrupts the capping process of viral RNA, including inhibiting CHIKV replication, reducing progeny viruses, and preventing cytopathic effects. It shows varying degrees of inhibitory activity against nsP1 of CHIKV and VEEV but lacks anti-SFV replication activity, displays cross-resistance with MADTP series compounds, and requires nsP2/nsP3 mutations to develop complete drug resistance. This inhibitor with varying inhibitory activity against nsP1 of CHIKV and VEEV can be widely applied to relevant studies on chikungunya virus infection and chikungunya fever[1][2][3][4].
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CHVB-066 | CHVB-066 is an alphavirus non-structural protein nsP1 inhibitor that exhibits varying degrees of inhibitory activity against nsP1 of CHIKV and VEEV. CHVB-066 inhibits MTase and GTase activities and disrupts the capping process of viral RNA, including inhibiting CHIKV replication, reducing progeny viruses, and preventing cytopathic effects. It shows varying degrees of inhibitory activity against nsP1 of CHIKV and VEEV but lacks anti-SFV replication activity, displays cross-resistance with MADTP series compounds, and requires nsP2/nsP3 mutations to develop complete drug resistance. This inhibitor with varying inhibitory activity against nsP1 of CHIKV and VEEV can be widely applied to relevant studies on chikungunya virus infection and chikungunya fever. | |||||||||||||||||||||
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- [1]. Besztercei B, et al. Three nitrogen atoms turn old kinase inhibitors into new targetable remedy[J]. bioRxiv, 2026: 2026.04. 11.717649. [Content Brief]
- [2]. Abdelnabi R, Kovacikova K, Moesslacher J, et al. Novel class of chikungunya virus small molecule inhibitors that targets the viral capping machinery[J]. Antimicrobial Agents and Chemotherapy, 2020, 64(7): 10.1128/aac. 00649-20. [Content Brief]
- [3]. Kovacikova K. Chikungunya virus nonstructural protein 1 as an antiviral target[J]. Antimicrob Agents Chemother, 2020, 64(12): e01788-20.
- [4]. Kovacikova K, van Hemert M J. Small-molecule inhibitors of chikungunya virus: mechanisms of action and antiviral drug resistance[J]. Antimicrobial agents and chemotherapy, 2020, 64(12): 10.1128/aac. 01788-20. [Content Brief]
Keywords
