3107145-13-8
Chemical Structure
CHIKV nsP2 protease-IN-2
- CAS No.: 3107145-13-8
- Formula:C26H38N2O4S
- Molecular Weight:474.66
IUPAC Name: (4-((1,1-dioxido-1,2-thiazinan-2-yl)methyl)-1-oxa-9-azaspiro[5.5]undecan-9-yl)(1-phenylcyclopentyl)methanone
InChIKey: RQLVVLAAHVIBPT-UHFFFAOYSA-N
SMILES: O=C(N(CC1)CCC21CC(CN(CCCC3)S3(=O)=O)CCO2)C4(C5=CC=CC=C5)CCCC4
Biological Activity: CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5 μM and 0.9 μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc). CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research[1].
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CHIKV nsP2 protease-IN-2 | CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5 μM and 0.9 μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc). CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research. | |||||||||||||||||||||
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