1613465-33-0
Chemical Structure
ML336
- CAS No.: 1613465-33-0
- Formula:C19H21N5O3
- Molecular Weight:367.40
IUPAC Name: (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide
InChIKey: DCAMTBFFNOHDAW-DYTRJAOYSA-N
SMILES: O=C(NC1=CC=CC=C1)C2=CC([N+]([O-])=O)=CC=C2/N=C3N(C)CCN(C)C/3
Biological Activity: ML336 is a Venezuelan equine encephalitis virus (VEEV) inhibitor with moderate passive blood-brain barrier permeability. ML336 inhibits viral RNA synthesis, virus-induced cytopathic effects and viral replication, reduces viral titers, and blocks the synthesis of VEEV genomic, subgenomic and template RNAs. ML336 can be used in studies related to VEEV infection[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML336 | 99.65% | ML336 is a Venezuelan equine encephalitis virus (VEEV) inhibitor with moderate passive blood-brain barrier permeability. ML336 inhibits viral RNA synthesis, virus-induced cytopathic effects and viral replication, reduces viral titers, and blocks the synthesis of VEEV genomic, subgenomic and template RNAs. ML336 can be used in studies related to VEEV infection. | ||||||||||||||||||||
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- [1]. Schroeder CE, et al. Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. Journal of medicinal chemistry. 2014 Oct 23;57(20):8608-21. [Content Brief]
- [2]. Skidmore AM, et al. Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production. Antiviral research. 2020 Feb;174:104674. [Content Brief]
Keywords
