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oxidative biotransformation

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-139428
    Hydroxydehydro Nifedipine Carboxylate

    		Drug Metabolite Others
    Hydroxydehydro Nifedipine Carboxylate is an inactive metabolite formed by the oxidative biotransformation of Nifedipine (HY-B0284) in the human body .
    Hydroxydehydro Nifedipine Carboxylate
  • HY-15042
    MK 0686

    		Bradykinin Receptor Metabolic Disease
    MK 0686, a potent bradykinin B1 receptor antagonist, demonstrates autoinduction of metabolism in rhesus monkeys after oral administration. It undergoes significant biotransformation primarily via oxidation pathways, leading to the formation of metabolites like M11 and M13 in rhesus liver microsomes. This metabolic induction is mediated by CYP2C75, as evidenced by increased mRNA expression, protein levels, and catalytic activity of this enzyme in hepatocytes and liver microsomes from MK 0686-treated animals. The autoinduction phenomenon suggests that MK 0686 enhances its own metabolism by upregulating CYP2C75, potentially influencing its systemic exposure and pharmacokinetics over time .
    MK 0686
  • HY-W701712
    Fenamiphos sulfone

    		Drug Derivative Others
    Fenamiphos sulfone is the oxidative metabolite of the organophosphorus pesticide fenamiphos. Fenamiphos sulfone undergoes biotransformation and accumulates in aquatic and terrestrial algal species .
    Fenamiphos sulfone

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