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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
oxidative biotransformation
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "oxidative biotransformation" in MCE Product Catalog:
Cat. No.: HY-W013058
CAS No.: 84852-53-9
Synonyms: DBDPE; 1,2-Bis(perbromophenyl)ethane
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Decabromodiphenyl ethane (DBDPE) is a brominated flame retardant. Decabromodiphenyl ethane induces ROS-related cytotoxicity and apoptosis in human hepatoma cells, causes hepatocyte damage through oxidative stress, endoplasmic reticulum stress and decreased CYP3A expression, and accumulates and undergoes biotransformation in animal tissues. Decabromodiphenyl ethane can be used to study the environmental toxicology and biological effects of brominated flame retardants .
Cat. No.: HY-139428
CAS No.: 34783-31-8
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Hydroxydehydro Nifedipine Carboxylate is an inactive metabolite formed by the oxidative biotransformation of Nifedipine (HY-B0284) in the human body .
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MK 0686, a potent bradykinin B1 receptor antagonist, demonstrates autoinduction of metabolism in rhesus monkeys after oral administration. It undergoes significant biotransformation primarily via oxidation pathways, leading to the formation of metabolites like M11 and M13 in rhesus liver microsomes. This metabolic induction is mediated by CYP2C75, as evidenced by increased mRNA expression, protein levels, and catalytic activity of this enzyme in hepatocytes and liver microsomes from MK 0686-treated animals. The autoinduction phenomenon suggests that MK 0686 enhances its own metabolism by upregulating CYP2C75, potentially influencing its systemic exposure and pharmacokinetics over time .
Cat. No.: HY-W701712
CAS No.: 31972-44-8
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Fenamiphos sulfone is the oxidative metabolite of the organophosphorus pesticide fenamiphos. Fenamiphos sulfone undergoes biotransformation and accumulates in aquatic and terrestrial algal species .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
