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quinolinone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) Connective Peptide (1) Drug Derivative (2) EGFR (1) Endogenous Metabolite (1) Fluorescent Dye (2) Fungal (2) Lipoxygenase (1) Monoamine Oxidase (2) Parasite (1) Reference Standards (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (2) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-34494

2,8-Quinolinediol 2,8-Dihydroxyquinoline; 8-Hydroxycarbostyril	Biochemical Assay Reagents	Others
8-Hydroxy-2(1H)-quinolinone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W010130

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone	Monoamine Oxidase	Neurological Disease
7-Hydroxy- 3, 4- dihydro- 2(1H) - quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC₅₀ of 183 μM, and has no effect on MAO-B .

HY-W344938

C.I. Acid yellow 3 Quinoline yellow	Fluorescent Dye	Others
C.I. Acid yellow 3 is an anionic quinolinone dye that is commonly used as a food additive, but also in the cosmetic and pharmaceutical industries .

HY-N4164

Schinifoline	Fungal Apoptosis	Infection Cancer
Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection .

HY-34763

7-Hydroxycarbostyril 7-Hydroxyquinolinone; 2,7-Dihydroxyquinoline	Drug Derivative	Others
7-Hydroxycarbostyril (7-Hydroxy-2(1H)-quinolinone) (Compound 7) is a quinolinone derivative. 7-Hydroxycarbostyril can be used for synthesis of Brexpiprazole (HY-15780). Brexpiprazole, a typical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor .

HY-158721

Penicinoline Marinamide	Endogenous Metabolite Parasite	Infection Cancer
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-150583

Chitin synthase inhibitor 2	Fungal	Inflammation/Immunology
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC₅₀ value of 0.09 mM and the K_i value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .

HY-N1637

1-Methyl-2-pentyl-4(1H)-quinolinone	Bacterial	Infection Cancer
1-Methyl-2-pentyl-4(1H)-quinolinone, a quinolone alkaloid isolated from the fruits of Evodia Rutaecarpa, possesses antibacterial and cytotoxic activities for cancer cells .

HY-N10456

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone	Bacterial	Infection
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC₅₀ value of 22 µM and an MIC₉₀ value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers .

HY-N10907

*4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-*	Bacterial	Infection
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .

HY-116574

Leiokinine A	Cholinesterase (ChE)	Others
Leiokinine A is a 4-quinolinone alkaloid and can be isolated from Esenbeckia leiocarpa .

HY-126467

TA-270	Lipoxygenase	Inflammation/Immunology
TA-270, a novel quinolinone derivative, is a potent inhibitor of 5-lipoxygenase that plays an important role in asthma research .

HY-167079

OPC-18750	Drug Derivative	Cardiovascular Disease
OPC-18750 is a novel positive inotropic agent and 2(lH)-quinolinone derivative. OPC-18750 displays positive inotropic and coronary vasodilating effects .

HY-W344938R

C.I. Acid yellow 3 (Standard) Quinoline yellow (Standard)	Fluorescent Dye Reference Standards	Others
C.I. Acid yellow 3 (Standard) is the analytical standard of C.I. Acid yellow 3. This product is intended for research and analytical applications. C.I. Acid yellow 3 is an anionic quinolinone dye that is commonly used as a food additive, but also in the cosmetic and pharmaceutical industries .

HY-W010130R

*7-Hydroxy-3,4-dihydro-2(1H)-quinolinone* (Standard)** 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone (Standard)	Reference Standards Monoamine Oxidase	Neurological Disease
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone (Standard) is the analytical standard of 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone. This product is intended for research and analytical applications. 7-?Hydroxy-?3,?4-?dihydro-?2(1H)?-?quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B .

HY-402321

2-Octyl-4(1H)-quinolone	Others	Others
2-Octyl-4(1H)-quinolone (Compound 14) is a quinolinone alkaloid that can be isolated from Ruta graveolens .

HY-W002905R

6-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Standard) 6-Hydroxyl-3.4-dihydro-2-(1H)-quinolinone (Standard)	Reference Standards
6-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Standard) is the analytical standard of 6-Hydroxy-3,4-dihydroquinolin-2(1H)-one. This product is intended for research and analytical applications.

HY-179529

EGFR/InhA-IN-1	EGFR Bacterial	Infection Cancer
EGFR/InhA-IN-1 (Compound 15) is an inhibitor of the anti-cancer target EGFR tyrosine kinase (1M17) (K_i = 0.05 μM) and the anti-tuberculosis target InhA enzyme (1OUZ) (K_i = 0.02 μM). EGFR/InhA-IN-1 exhibits anti-proliferative activity against A549 cells, with an IC₅₀ of 10.38 μM. EGFR/InhA-IN-1 has inhibitory activity against Mycobacterium tuberculosis H37Rv, with a MIC of 6.25 μM. EGFR/InhA-IN-1 can be used for research on non-small cell lung cancer and Mycobacterium tuberculosis infection .

HY-182449

CCT365386	Bcl-2 Family	Cancer
CCT365386 is a BCL6 inhibitor. CCT365386 serves as an optimized lead compound for cell-active BCL6 degraders (including CCT369260 (HY-129188)). CCT365386 can be used in the research of B-cell lymphoma .

HY-180913

FQI2-34	Connective Peptide	Cancer
FQI2-34 is an orally active TFCP2 (LSF) small molecule allosteric inhibitor. FQI2-34 directly binds to the LSF protein (K_i = 63 nM), inhibits the oligomerization of LSF, efficiently suppresses the transcriptional activity of LSF (IC₅₀ = 48 nM), and interferes with the SF-DNA interaction. FQI2-34 exhibits significant anti-proliferative activity against Huh7 cells and induces tumor regression in mouse models. FQI2-34 can be used for research on liver cancer .

Cat. No.	Product Name	Type

HY-W344938

C.I. Acid yellow 3 Quinoline yellow	Biochemical Assay Reagents
C.I. Acid yellow 3 is an anionic quinolinone dye that is commonly used as a food additive, but also in the cosmetic and pharmaceutical industries .

HY-W344938R

C.I. Acid yellow 3 (Standard) Quinoline yellow (Standard)	Biochemical Assay Reagents
C.I. Acid yellow 3 (Standard) is the analytical standard of C.I. Acid yellow 3. This product is intended for research and analytical applications. C.I. Acid yellow 3 is an anionic quinolinone dye that is commonly used as a food additive, but also in the cosmetic and pharmaceutical industries .

Schinifoline	Zanthoxylum bungeanum Maxim. Alkaloids Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification Cancer	Fungal Apoptosis
Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection .

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

1-Methyl-2-pentyl-4(1H)-quinolinone	Infection Alkaloids other families Classification of Application Fields Quinoline Alkaloids Plants Disease Research Fields Source Classification	Bacterial
1-Methyl-2-pentyl-4(1H)-quinolinone, a quinolone alkaloid isolated from the fruits of Evodia Rutaecarpa, possesses antibacterial and cytotoxic activities for cancer cells .

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone	Natural Products Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley Source Classification	Bacterial
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC₅₀ value of 22 µM and an MIC₉₀ value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers .

*4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl-*	Alkaloids Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley Source Classification	Bacterial
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2) is a quinolone alkaloid that can be isolated from Cnidium. 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- has methicillin-resistant Staphylococcus aureus (MRSA) activity, with MIC values of 32 μg/mL (ATCC 33591) and 16 μM/mL (ATCC 25923), respectively .

Leiokinine A	Alkaloids Esenbeckia leiocarpa Engl. Rutaceae Quinoline Alkaloids Plants Source Classification	Cholinesterase (ChE)
Leiokinine A is a 4-quinolinone alkaloid and can be isolated from Esenbeckia leiocarpa .

2-Octyl-4(1H)-quinolone	Alkaloids Other Alkaloids Ruta graveolens Linn. Rutaceae Plants Source Classification	Others
2-Octyl-4(1H)-quinolone (Compound 14) is a quinolinone alkaloid that can be isolated from Ruta graveolens .

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quinolinone

Inhibitors & Agonists

Biochemical Assay Reagents

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Natural
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