80554-58-1
Chemical Structure
Schinifoline
- CAS No.: 80554-58-1
- Formula:C17H23NO
- Molecular Weight:257.37
IUPAC Name: 2-heptyl-1-methylquinolin-4(1H)-one
InChIKey: HCUSLQJBGQJQCB-UHFFFAOYSA-N
SMILES: O=C1C=C(CCCCCCC)N(C)C2=C1C=CC=C2
Biological Activity: Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection[1][2].
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Schinifoline | 99.55% | Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection. | ||||||||||||||||||||
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Similarity Score 0.94
HY-N16361-Methyl-2-nonyl-4(1H)-quinolone -
Similarity Score 0.93
HY-N16371-Methyl-2-pentyl-4(1H)-quinolinone -
Similarity Score 0.90
HY-N16381-Methyl-2-undecyl-4(1H)-quinolone -
Similarity Score 0.87
![1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone Chemical Structure](//file.medchemexpress.com/product_pic/hy-n0968.gif)
HY-N09681-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone -
Similarity Score 0.87
HY-N109074(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- -
Similarity Score 0.85
HY-N2517Dihydroevocarpine -
Similarity Score 0.82
HY-N104561-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone -
Similarity Score 0.82
HY-N2060Evocarpine -
Similarity Score 0.80
HY-1295032-Heptyl-4-quinolone -
Explore the MedChemAI to find more analogs
![1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone Chemical Structure](http://file.medchemexpress.com/product_pic/hy-n0968.gif)
References
- [1]. Wang CF, et al. Radiosensitizing effect of schinifoline from Zanthoxylum schinifolium Sieb et Zucc on human non-small cell lung cancer A549 cells: a preliminary in vitro investigation. Molecules. 2014 Dec 1;19(12):20128-38. [Content Brief]
- [2]. Lu L, et al. Whole transcriptome analysis of schinifoline treatment in Caenorhabditis elegans infected with Candida albicans. Mol Immunol. 2021 Jul;135:312-319. [Content Brief]
