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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
septic inflammatory response
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "septic inflammatory response" in MCE Product Catalog:
8
Research Areas:
8
Research Areas:
3
3 Cited Publications
Cat. No.: HY-N1388
CAS No.: 104012-37-5
Category:
Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Inflammation/Immunology Tephrosia purpurea (L.) Pers.
Target:
Target:
Research Areas:
M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .
Cat. No.: HY-W929472
CAS No.: 87984-82-5
Target:
Drug Metabolite PPAR NOD-like Receptor (NLR) NF-κB Reactive Oxygen Species (ROS) Autophagy Caspase TNF Receptor NO Synthase Interleukin Related Apoptosis
Research Areas:
13 (S)-HOTrE is an oxylipin metabolite of α-Linolenic acid (HY-N0728). 13 (S)-HOTrE mediates the inactivation of the NLRP3 inflammasome through the PPAR-γ pathway to exert anti-inflammatory effects. 13 (S)-HOTrE inhibits NF-κB nuclear translocation, ROS production, autophagy and IL-1β levels, induces apoptosis, and increases IL-10 levels. 13 (S)-HOTrE alleviates LPS-induced inflammatory responses in macrophages, prolongs the survival time of septic mice, and regulates the immunometabolic phenotype in parenteral nutrition mouse models. 13 (S)-HOTrE can be used in the research of immune and inflammation-related diseases .
Cat. No.: HY-113919
CAS No.: 11023-94-2
Category:
other families Flavonoids Phenols Polyphenols Plants Dihydrochalcones Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-111303
CAS No.: 848193-72-6
Target:
Research Areas:
CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM) . CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research .
Cat. No.: HY-N1388R
CAS No.: 104012-37-5
Target:
Cat. No.: HY-153452
CAS No.: 2455424-51-6
Target:
Research Areas:
PCSK9-IN-16 is a potent PCSK9 inhibitor. PCSK9-IN-16 is extracted from patent WO2020150474, example 87, has the potential for hypercholesterolemia and other cardiovascular diseases research .
Cat. No.: HY-176466
CAS No.: 143484-41-7
Research Areas:
ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS)-induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6). The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock .
Cat. No.: HY-103639AR
CAS No.: 613263-00-6
Research Areas:
M62812 (Standard) is the analytical standard of M62812 (HY-103639A). This product is intended for research and analytical applications. M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .
Cat. No.: HY-L014
1,770 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
MCE owns a unique collection of 1,770 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
