87984-82-5
Chemical Structure
13(S)-HOTrE
- CAS No.: 87984-82-5
- Formula:C18H30O3
- Molecular Weight:294.43
InChIKey: KLLGGGQNRTVBSU-FQSPHKRJSA-N
SMILES: OC(CCCCCCC/C=C\C=C\[C@@H](O)C/C=C\CC)=O
Biological Activity: 13 (S)-HOTrE is an oxylipin metabolite of α-Linolenic acid (HY-N0728). 13 (S)-HOTrE mediates the inactivation of the NLRP3 inflammasome through the PPAR-γ pathway to exert anti-inflammatory effects. 13 (S)-HOTrE inhibits NF-κB nuclear translocation, ROS production, autophagy and IL-1β levels, induces apoptosis, and increases IL-10 levels. 13 (S)-HOTrE alleviates LPS-induced inflammatory responses in macrophages, prolongs the survival time of septic mice, and regulates the immunometabolic phenotype in parenteral nutrition mouse models. 13 (S)-HOTrE can be used in the research of immune and inflammation-related diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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13(S)-HOTrE | 99.9% | 13 (S)-HOTrE is an oxylipin metabolite of α-Linolenic acid (HY-N0728). 13 (S)-HOTrE mediates the inactivation of the NLRP3 inflammasome through the PPAR-γ pathway to exert anti-inflammatory effects. 13 (S)-HOTrE inhibits NF-κB nuclear translocation, ROS production, autophagy and IL-1β levels, induces apoptosis, and increases IL-10 levels. 13 (S)-HOTrE alleviates LPS-induced inflammatory responses in macrophages, prolongs the survival time of septic mice, and regulates the immunometabolic phenotype in parenteral nutrition mouse models. 13 (S)-HOTrE can be used in the research of immune and inflammation-related diseases. | ||||||||||||||||||||
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- [1]. Kumar N, et al. 15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome. Scientific reports. 2016 Aug 18;6:31649. [Content Brief]
- [2]. Cambiaggi L, et al. The Role of α-Linolenic Acid and Its Oxylipins in Human Cardiovascular Diseases. International journal of molecular sciences. 2023 Mar 24;24(7):6110. [Content Brief]
Keywords
