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9 Results for "
solvatochromic probe
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "solvatochromic probe" in MCE Product Catalog:
Cat. No.: HY-N16308
CAS No.: 3091879-77-2
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Cat. No.: HY-134096
CAS No.: 78323-98-5
Synonyms: DNS-M
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Dansyl-morpholine (DNS-M) is a Fluorescent probe for lipid droplet imaging, cancer cell discrimination, and real-time tracking of lipid droplet dynamics. As a solvatochromic probe with a donor-π-acceptor structure, it relies on hydrophobic interaction for its mechanism of action: its good lipophilicity, confirmed by an oil-water partition coefficient LogP = 2.35, allows it to rapidly penetrate cell membranes, and it specifically localizes to the hydrophobic core of lipid droplets; its fluorescence is strongly enhanced in the nonpolar environment of lipid droplets, while it emits very weak fluorescence in polar environments like PBS buffer, and it exhibits a bathochromic shift in emission wavelength with increasing solvent polarity. It has negligible cytotoxicity, with cell viability remaining over 95% after 24-hour incubation with 100 μM of the probe, and it possesses excellent photostability, retaining over 97% of initial fluorescence intensity after 60 continuous laser scans. For cell imaging applications, its excitation/emission wavelengths for lipid droplet labeling are Ex/Em = 405/480−540 nm, and in a simulative lipid environment O/W emulsion, it has an excitation wavelength of ~346 nm and emission wavelength of ~500 nm, giving a Stokes shift of 154 nm[1].
Cat. No.: HY-D3090
CAS No.: 2757682-04-3
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NRLD is a lipid droplet-targeting solvatochromic fluorescent probe developed based on Nile Red (HY-D0718), which can target lipid droplets and sense the non-polar lipid microenvironment inside lipid droplets. NRLD exhibits superior lipid droplet-targeting selectivity compared to the parent Nile Red dye in HeLa cell imaging. NRLD achieves detection relying on the solvatochromic effect generated by excited-state charge transfer, and its emission wavelength shifts according to the local polarity changes of the microenvironment it locates in: the more compact and ordered the lipid packing and the lower the environmental polarity, the more blue-shifted the emission; the looser the lipid packing or the stronger the hydration and the higher the environmental polarity, the more red-shifted the emission. NRLD shows blue shift in the non-polar oil core of lipid droplets and red shift in high-polarity environments such as phosphate buffer .
Cat. No.: HY-D3110
CAS No.: 2757682-03-2
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NRGolgi is a Nile Red-based solvatochromic fluorescent probe targeted to the Golgi apparatus. NRGolgi localizes selectively to the Golgi membrane via its myristic acid group, and leverages the property of its emission wavelength undergoing blue/red shift with local polarity to quantitatively detect the lipid order of the Golgi membrane in living cells using dual-emission ratiometric imaging (550-600 nm / 600-650 nm). NRGolgi is suitable for real-time monitoring of Golgi lipid order under conditions of oxidative stress, mechanical stress, and altered cholesterol metabolism .
Cat. No.: HY-D3091
CAS No.: 2757681-99-3
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NRLyso is a lysosome-targeted solvatochromic fluorescent probe derived from Nile Red (HY-D0718). It can localize to lysosomes and is applicable for imaging lysosomal lipid order and polarity. The excitation wavelength of NRLyso is 520 nm, and its emission maximum varies with the environment. NRLyso partitions well into lipid membranes: it exhibits fluorescence enhancement and emission blue-shift in low-polarity, tightly packed lipid environments, while shows emission red-shift in more polar, disordered lipid environments. NRLyso maintains organelle specificity under oxidative and hyperosmotic stress conditions, and can detect changes in lysosomal lipid order and polarity in response to these stresses, cholesterol extraction, and cholesterol enrichment .
Cat. No.: HY-D3087
CAS No.: 1966158-27-9
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Lyso-OC is a two-photon fluorescent probe that enables real-time monitoring of autophagy through ultrasensitive detection of lysosomal polarity changes. Lyso-OC possesses a coumarin (HY-N0709) solvatochromic group and a morpholine lysosome-targeting group, allowing selective lysosomal localization in living cells. Lyso-OC emits strong fluorescence in low-polarity lysosomes, whereas in high-polarity autolysosomes formed during autophagy, its fluorescence intensity decreases and the emission peak shifts by approximately 30 nm. For two-photon detection, the excitation/emission wavelengths of Lyso-OC are 760/490-550 nm, and its one-photon excitation wavelength is 375 nm. Lyso-OC can be used in cancer-related research .
Cat. No.: HY-D3092
CAS No.: 2757682-01-0
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NRERf is an endoplasmic reticulum (ER)-targeted solvatochromic fluorescent probe based on Nile Red (HY-D0718). It possesses ER-targeting capability and can sense changes in local polarity and lipid order of biological membranes. NRERf undergoes excited-state charge transfer, with its emission color changing according to local polarity: the tightly packed, low-polarity liquid-ordered phase (Lo) induces a blue-shifted emission, while the high-polarity liquid-disordered phase (Ld) induces a red-shifted emission. The emission wavelength of NRERf varies with the environment. NRERf can be used to detect changes in lipid order and polarity induced in the ER by cholesterol extraction/enrichment, oxidative stress, and hyperosmotic shock .
Cat. No.: HY-D3071
CAS No.: 1510814-96-6
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LW-1 is a fluorescent probe targeting polarity detection of lipid droplets (LD). LW-1 produces a strong solvatochromic effect via the intramolecular charge transfer (ICT) mechanism: as environmental polarity increases, the emission wavelength red-shifts and the fluorescence intensity decreases significantly (emission at 557 nm in toluene and 642 nm in acetonitrile, with an 85 nm red-shift); fluorescence enhances in low-polarity lipid droplets. LW-1 can be used for lipid droplet polarity detection, differentiation between cancer cells and normal cells, monitoring of lipid droplet polarity changes under different physiological conditions such as starvation, oleic acid treatment and oxidative stress, as well as ex vivo imaging of polarity changes in lung tissues of asthmatic mice. The detection wavelength for cell imaging with LW-1 is Ex/Em = 405/500-550 nm (green channel) .
Cat. No.: HY-172754
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
