3091879-77-2
Chemical Structure
ER-Laurdan
- CAS No.: 3091879-77-2
- Formula:C54H80F5N3O13
- Molecular Weight:1074.22
IUPAC Name: N-(2-(6-dodecanoylnaphthalen-2-yl)-4-oxo-8,11,14,17,20,23,26,29,32,35-decaoxa-2,5-diazaheptatriacontan-37-yl)-2,3,4,5,6-pentafluorobenzamide
InChIKey: GMCMCXYWOHEPDP-UHFFFAOYSA-N
SMILES: O=C(C1=C(F)C(F)=C(F)C(F)=C1F)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CN(C)C2=CC=C3C(C=CC(C(CCCCCCCCCCC)=O)=C3)=C2)=O
Biological Activity: ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the endoplasmic reticulum (ER). As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes[1][2].
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ER-Laurdan | ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the endoplasmic reticulum (ER). As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes. | |||||||||||||||||||||
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- [1]. Wong AM, et al. Organelle-Targeted Laurdans Measure Heterogeneity in Subcellular Membranes and Their Responses to Saturated Lipid Stress. ACS Chem Biol. 2024;19(8):1773-1785. [Content Brief]
- [2]. Tsai Y T, et al. 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway[J]. Cell chemical biology, 2026, 33(1): 45-58. e8.
Keywords
