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Results for "

vWF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Fluorescent Dye (2) Integrin (9) Small Interfering RNA (siRNA) (3) Transmembrane Glycoprotein (1)
By Research Areas:	Cardiovascular Disease (12) Infection (1) Inflammation/Immunology (3)
Oligonucleotides:	Aptamers (6) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99227

Caplacizumab (His Tag) 1 Publications Verification ALX-0681; ALX-0081	Integrin Transmembrane Glycoprotein	Cardiovascular Disease
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor *(vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF* with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .

HY-P5354

*FRETS-VWF73* 1 Publications Verification	Fluorescent Dye	Cardiovascular Disease
FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). FRETS-VWF73 is a predictive tool for thrombotic thrombocytopenic purpura .

HY-153999A

Rondaptivon pegol sodium BT200 sodium	Integrin Apoptosis	Cardiovascular Disease Inflammation/Immunology
Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC₅₀ of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .

HY-138053

Ristocetin A sulfate Ristomycin III	Antibiotic	Cardiovascular Disease Infection
Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections .

HY-P5354A

*FRETS-VWF73 TFA* 1 Publications Verification	Fluorescent Dye	Others
FRETS-VWF73 TFA, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm) .

HY-153999

Rondaptivon pegol BT200	Integrin Apoptosis	Cardiovascular Disease Inflammation/Immunology
Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC₅₀ of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .

HY-147079A

Egaptivon pegol sodium ARC 1779 sodium	Integrin	Cardiovascular Disease
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-147079

Egaptivon pegol ARC 1779	Integrin	Cardiovascular Disease
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-P990544

*Anti-vWF* Antibody** AJW 200; AJvW 2	Integrin	Inflammation/Immunology
Anti-vWF Antibody is a humanized antibody expressed in CHO cells that targets *vWF. The Anti-vWF* Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.62 kDa. The isotype control for Anti-vWF Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-138019

SP-8008	Integrin	Cardiovascular Disease
SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC₅₀ of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation .

HY-RS15735

VWF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VWF Human Pre-designed siRNA Set A contains three designed siRNAs for VWF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VWF Human Pre-designed siRNA Set A VWF Human Pre-designed siRNA Set A

HY-RS17403

Vwf Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vwf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vwf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vwf Mouse Pre-designed siRNA Set A Vwf Mouse Pre-designed siRNA Set A

HY-RS23858

Vwf Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vwf Rat Pre-designed siRNA Set A contains three designed siRNAs for Vwf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vwf Rat Pre-designed siRNA Set A Vwf Rat Pre-designed siRNA Set A

HY-153998

BT100 sodium	Integrin	Cardiovascular Disease
BT100 (sodium), a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .

HY-N19251

Sulfobacin B	Integrin	Cardiovascular Disease
Sulfobacin B is a competitive von Willebrand factor receptor GPIb/IX inhibitor with an IC₅₀ of 2.2 μM. Sulfobacin B inhibits binding of von Willebrand factor to GPIb/IX in a competitive manner. Sulfobacin B can be used for the research of thrombosis .

Cat. No.	Product Name	Target	Research Area

HY-P5354

*FRETS-VWF73* 1 Publications Verification	Fluorescent Dye	Cardiovascular Disease
FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). FRETS-VWF73 is a predictive tool for thrombotic thrombocytopenic purpura .

HY-P5354A

*FRETS-VWF73 TFA* 1 Publications Verification	Fluorescent Dye	Others
FRETS-VWF73 TFA, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99227

Caplacizumab (His Tag) 1 Publications Verification ALX-0681; ALX-0081	Integrin Transmembrane Glycoprotein	Cardiovascular Disease
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor *(vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF* with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .

HY-P99875

Efanesoctocog alfa BIVV-001; Altuvoct	Inhibitory Antibodies	Cardiovascular Disease
Efanesoctocog alfa is a B domain-deleted single-chain Factor VIII (FVIII) connected to D'D3 domain of von Willebrand Factor (vWF). Efanesoctocog alfa has an extended half-life. Efanesoctocog alfa can be used for the study of inherited hemophilia A .

HY-P990544

*Anti-vWF* Antibody** AJW 200; AJvW 2	Integrin	Inflammation/Immunology
Anti-vWF Antibody is a humanized antibody expressed in CHO cells that targets *vWF. The Anti-vWF* Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.62 kDa. The isotype control for Anti-vWF Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N19251

Sulfobacin B	Structural Classification Natural Products Microorganisms Source Classification	Integrin
Sulfobacin B is a competitive von Willebrand factor receptor GPIb/IX inhibitor with an IC₅₀ of 2.2 μM. Sulfobacin B inhibits binding of von Willebrand factor to GPIb/IX in a competitive manner. Sulfobacin B can be used for the research of thrombosis .

Species:	Human (2)
Tag:	His (2)
Source:	CHO (1) CHO (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73541

	*Von Willebrand Factor/vWF* Protein, Human (CHO, His)** von Willebrand factor; vWF; von Willebrand antigen II; F8vWF	Human	CHO
	Von Willebrand Factor/vWF Protein, Human (CHO, His) is the recombinant human-derived Von Willebrand Factor/vWF protein, expressed by CHO, with C-His labeled tag.

HY-P79144

	ADAMTS13 Protein, Human (CHO, His) ADAM-TS 13; ADAM-TS13; ADAMTS-13von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease; A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 13	Human	CHO
	The ADAMTS13 protein, a metalloproteinase, has a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. It cleaves von Willebrand Factor and defects in this gene cause thrombotic thrombocytopenic purpura. Alternative splicing generates multiple transcript variants. ADAMTS13 is broadly expressed in various tissues, including the liver, testis, and 24 other tissues. ADAMTS13 Protein, Human (CHO, His) is the recombinant human-derived ADAMTS13, expressed by CHO, with C-10His labeled tag. The total length of ADAMTS13 Protein, Human (CHO, His) is 655 a.a.*.

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Host:	Rabbit (3)
Reactivity:	Human (1) Rat (2)
Application:	IHC-P (2) WB (3) FC (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82661

	von Willebrand Factor Antibody (YA2406) vWF; von Willebrand factor; von Willebrand antigen II; F8vWF	WB, IHC-P	Rat
	von Willebrand Factor Antibody (YA2406) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to von Willebrand Factor.

HY-P82661A

	von Willebrand Factor Antibody (YA2406)(PBS only) vWF; von Willebrand factor; von Willebrand antigen II; F8vWF	WB, IHC-P	Rat
	von Willebrand Factor Antibody (YA2406) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to von Willebrand Factor.

HY-P82257

	ADAMTS13 Antibody (YA2002) ADAMTS13; ADAM-TS; ADAM-TS13; ADAMTS-13; ADAM-TS 13; C9orf8; TTP; vWF-CP; vWFCP	WB, FC	Human
	ADAMTS13 Antibody (YA2002) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAMTS13.