2. Stem Cell/Wnt
  3. Wnt
  4. SEN461

SEN461 is a potent and orally active Wnt pathway inhibitor. SEN461 shows effective anti-tumor activity and can be used for GBM research.

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SEN461

SEN461 Estructura química

No. CAS : 1287727-28-9

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SEN461 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Wnt:

Ver todas las isoformas
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

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Descripciòn

SEN461 is a potent and orally active Wnt pathway inhibitor. SEN461 shows effective anti-tumor activity and can be used for GBM research[1].

Cellular Effect
Cell Line Type Value Description References
DLD-1 IC50
0.71 μM
Compound: 33, SEN461
Growth inhibition of human DLD1 cells after 14 to 21 days by soft agar assay
Growth inhibition of human DLD1 cells after 14 to 21 days by soft agar assay
[PMID: 25847770]
NCI-N87 IC50
1.8 μM
Compound: 33, SEN461
Growth inhibition of human NCI-N87 cells after 14 to 21 days by soft agar assay
Growth inhibition of human NCI-N87 cells after 14 to 21 days by soft agar assay
[PMID: 25847770]
Peso molecular

486.56

Fòrmula

C25H34N4O6
No. CAS
SMILES

O=C(N(C1=C(C2=O)C=C(C=C1)OC)C)N2C[C@H]3CC[C@@H](CC3)C(N4CCN(CC4)C(COC)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
Referencias
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SEN461 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEN4611287727-28-9SEN 461SEN-461Wntβ-catenin,structure-activity relationshipglioblastomaInhibitorinhibitorinhibit

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Nombre del producto:
SEN461
Cat. No.:
HY-120864
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