1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. HMG-CoA Reductase (HMGCR)
    Reactive Oxygen Species
  3. Simvastatin acid ammonium

Simvastatin acid ammonium (Synonyms: Tenivastatin ammonium)

Cat. No.: HY-119695A Purity: 99.32%
Handling Instructions

Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

For research use only. We do not sell to patients.

Simvastatin acid ammonium Chemical Structure

Simvastatin acid ammonium Chemical Structure

CAS No. : 139893-43-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 550 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 550 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Simvastatin acid ammonium:

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  • Biological Activity

  • Purity & Documentation

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Description

Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

IC50 & Target

HMG-CoA reductase, Reactive oxygen species[1][2]

In Vitro

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: hCM and HEK293 (transfected with OATP3A1)
Concentration: 0.1, 1, 10 and 20 μM
Incubation Time: 24 h
Result: Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.
Molecular Weight

453.61

Formula

C25H43NO6

CAS No.
SMILES

O=C(C[[email protected]@H](C[[email protected]@H](CC[[email protected]]1[[email protected]](C=CC2=C[[email protected]@H](C[[email protected]@H]([[email protected]]12[H])OC(C(C)(CC)C)=O)C)C)O)O)[O-].[NH4+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 11.11 mg/mL (24.49 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2045 mL 11.0227 mL 22.0454 mL
5 mM 0.4409 mL 2.2045 mL 4.4091 mL
10 mM 0.2205 mL 1.1023 mL 2.2045 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.11 mg/mL (2.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.11 mg/mL (2.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.11 mg/mL (2.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Simvastatin acid ammonium
Cat. No.:
HY-119695A
Quantity:
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