1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Simvastatin acid ammonium

Simvastatin acid ammonium (Synonyms: Tenivastatin ammonium)

Cat. No.: HY-119695A
Handling Instructions

Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

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Simvastatin acid ammonium Chemical Structure

Simvastatin acid ammonium Chemical Structure

CAS No. : 139893-43-9

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Description

Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

There is a pH-dependent effect on organic anion transporting polypeptide 3A1 (OATP3A1) uptake, with more efficient simvastatin acid uptake at pH5.5 in HEK293 cells transfected with the OATP3A1 gene. The Michaelis-Menten constant (Km) for simvastatin acid uptake by OATP3A1 was 0.017 μM and the Vmax was 0.995 fmol/min/105 cells[1].

Molecular Weight

453.61

Formula

C₂₅H₄₃NO₆

CAS No.

139893-43-9

SMILES

O=C(C[[email protected]@H](C[[email protected]@H](CC[[email protected]]1[[email protected]](C=CC2=C[[email protected]@H](C[[email protected]@H]([[email protected]]12[H])OC(C(C)(CC)C)=O)C)C)O)O)[O-].[NH4+]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Simvastatin acidTenivastatinEndogenous MetabolitemetabolitesimvastatinlactoneCYP3A4/5intestinalliverreactiveoxygen speciesOATP3A1Inhibitorinhibitorinhibit

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Simvastatin acid ammonium
Cat. No.:
HY-119695A
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