1. Metabolic Enzyme/Protease
  2. HMG-CoA Reductase (HMGCR)
  3. Simvastatin hydroxy acid sodium

Simvastatin hydroxy acid sodium (Synonyms: Tenivastatin sodium; Simvastatin Impurity A sodium)

Cat. No.: HY-115292
Handling Instructions

Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) is an active hydrolytic metabolite of Simvastatin (HY-17502). Simvastatin shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM.

For research use only. We do not sell to patients.

Simvastatin hydroxy acid sodium Chemical Structure

Simvastatin hydroxy acid sodium Chemical Structure

CAS No. : 101314-97-0

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Description

Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) is an active hydrolytic metabolite of Simvastatin (HY-17502)[1]. Simvastatin shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[2].

In Vitro

Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1].
Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

458.56

Formula

C₂₅H₃₉NaO₆

CAS No.

101314-97-0

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Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Simvastatin hydroxy acidTenivastatinSimvastatin Impurity AHMG-CoA Reductase (HMGCR)prodrugHMG-CoAInhibitorinhibitorinhibit

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Product Name:
Simvastatin hydroxy acid sodium
Cat. No.:
HY-115292
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