1. Apoptosis
  2. Apoptosis
  3. SSK1

SSK1 

Cat. No.: HY-138936
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SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted prodrug attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis.

For research use only. We do not sell to patients.

SSK1 Chemical Structure

SSK1 Chemical Structure

CAS No. : 2629250-69-5

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Description

SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted prodrug attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis[1].

In Vitro

SSK1 (0.5 µM; 12-72 hours) activates the phosphorylation levels of both p38 MAPK and MKK3/MKK6 in senescent cells. SSK1 kills senescent cells through the activation of the p38 MAPK signaling pathway. SSK1 is able to induce mitochondrial DNA damage in senescent cells[1].
SSK1 (0.01-1 µM; 3 days) selectively and potently eliminates β-galactosidase-positive senescent cells within a wide therapeutic window[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Primary mouse fibroblasts
Concentration: 0.5 µM
Incubation Time: 12 hours, 24 hours, 36 hours, 48 hours, 72 hours
Result: Both p38 MAPK and MKK3/MKK6 were activated by phosphorylation in senescent cells.
In Vivo

SSK1 (0.5 mg/kg; i.p.; two days every week; for four weeks) could eliminate senescent cells and decrease senescence-associated markers in lung-injured mice[1].
In aged mice (20-month-old), SSK1 (0.5 mg/kg; 3 days every 2 weeks for 8 weeks) effectively clears senescent cells in different tissues, decreases the senescence- and age-associated gene signatures, attenuates low-grade local and systemic inflammation, and restores physical function[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (3-6-month-old) were subjected to transtracheal injection of Bleomycin[1]
Dosage: 0.5 mg/kg
Administration: Intraperitoneally injection; two days every week; for four weeks
Result: SSK1 significantly reduced the percentage of SA-β-gal-positive cells in lung by 3.8-fold compared with that in vehicle-treated lung-injured mice
Molecular Weight

788.61

Formula

C₃₁H₃₄F₂N₄O₁₈

CAS No.
SMILES

CC(O[[email protected]]([[email protected]]([[email protected]]1OC(C)=O)OC(C)=O)[[email protected]@H](O[[email protected]@H]1COC(C)=O)OC(C=CC(COC(NC(C=CN2[[email protected]](C(F)([[email protected]@H]3O)F)([H])O[[email protected]@H]3CO)=NC2=O)=O)=C4)=C4[N+]([O-])=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SSK1SSK 1SSK-1Apoptosissenescencelysosomalβ-galactosidaseanti-inflammatoryp38Inhibitorinhibitorinhibit

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