XRCC6 - X-ray repair cross complementing 6 Gene

Also Known as ML8; KU70; TLAA; CTC75; CTCBF; G22P1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2547

About XRCC6

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,621,295-41,664,041 (from NCBI)

This gene has 8 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 152.7), lymph node (RPKM 92.6) and 25 other tissues.

Summary

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

XRCC6 Products (4)

mRNA	Protein	Name
NM_001288976.2	NP_001275905.1	X-ray repair cross-complementing protein 6 isoform 1
NM_001288977.2	NP_001275906.1	X-ray repair cross-complementing protein 6 isoform 2
NM_001288978.2	NP_001275907.1	X-ray repair cross-complementing protein 6 isoform 3
NM_001469.5	NP_001460.1	X-ray repair cross-complementing protein 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5'-deoxyribose-5-phosphate lyase activity	IMP IMP: Inferred from mutant phenotype	20383123	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	9368068	GOA
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	9368068	GOA
contributes to DNA end binding	IDA IDA: Inferred from direct assay	9368068	GOA
enables DNA helicase activity	IDA IDA: Inferred from direct assay	9368068	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	15159402	GOA
contributes to double-stranded telomeric DNA binding	IDA IDA: Inferred from direct assay	10409678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8621488	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12377759	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	23555801	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18809223	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	26359349	GOA
involved in double-strand break repair via classical nonhomologous end joining	IDA IDA: Inferred from direct assay	24095731	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	20383123	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	8621488	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12145306	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18809223	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	22504299	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18809223	GOA
involved in regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25852083	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DNA-dependent protein kinase complex	IPI IPI: Inferred from physical interaction	28840859	GOA
part of DNA-dependent protein kinase-DNA ligase 4 complex	IDA IDA: Inferred from direct assay	34352203	GOA
part of Ku70:Ku80 complex	IDA IDA: Inferred from direct assay	20383123	GOA
part of Ku70:Ku80 complex	IPI IPI: Inferred from physical interaction	11493912	GOA
part of nonhomologous end joining complex	IDA IDA: Inferred from direct assay	20383123	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	27829214	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12145306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRCC6 Protein Structure

Ku_N

Ku_C

SAP

0
100
200
300
400
500
609 a.a.

Protein Preferred Names	Protein Names
X-ray repair cross-complementing protein 6	5'-dRP lyase Ku70

XRCC6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XRCC6	P12956	TPT1	Homo sapiens	P13693	Anti Bait CoIP	22451927
Intra	XRCC6	P12956	SIRT1	Homo sapiens	Q96EB6	Deacetylase Assay	15205477
Intra	XRCC6	P12956	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	17334224
Intra	XRCC6	P12956	HMBOX1	Homo sapiens	Q6NT76	Anti Bait CoIP	23685356
Intra	XRCC6	P12956	PRKDC	Homo sapiens	P78527	Anti Tag CoIP	26496610
Intra	XRCC6	P12956	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	17308091
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	EM	17159921
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	17283121
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	X-Ray Diffraction	11493912
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	17308091
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	26496610
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	33961781
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	22451927
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	25574025
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	28514442
Intra	XRCC6	P12956	XRCC5	Homo sapiens	P13010	Validated Y2H	32296183
Intra	XRCC6	P12956	TP53	Homo sapiens	P04637	Anti Bait CoIP	15782130
Intra	XRCC6	P12956	WRN	Homo sapiens	Q14191	GMS	14734561
Intra	XRCC6	P12956	WRN	Homo sapiens	Q14191	Anti Tag CoIP	33961781
Intra	XRCC6	P12956	WRN	Homo sapiens	Q14191	Anti Tag CoIP	26496610
Intra	XRCC6	P12956	WRN	Homo sapiens	Q14191	Anti Tag CoIP	28514442
Intra	XRCC6	P12956	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	XRCC6	P12956	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	XRCC6	P12956	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	XRCC6	P12956	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	XRCC6	P12956	HTT	Homo sapiens	P42858	Y2H	15383276
Intra	XRCC6	P12956	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	XRCC6	P12956	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	XRCC6	P12956	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	XRCC6	P12956	BAX	Homo sapiens	Q07812	Anti Bait CoIP	15205477
Intra	XRCC6	P12956	ARAP1	Homo sapiens	Q96P48	Anti Tag CoIP	16169070
Intra	XRCC6	P12956	PPID	Homo sapiens	Q08752	Anti Tag CoIP	21146485
Intra	XRCC6	P12956	XRCC4	Homo sapiens	Q13426	Anti Bait CoIP	17124166
Intra	XRCC6	P12956	XRCC4	Homo sapiens	Q13426	Crosslink	17124166
Intra	XRCC6	P12956	XRCC4	Homo sapiens	Q13426	Anti Tag CoIP	26496610
Intra	XRCC6	P12956	DEAF1	Homo sapiens	O75398	Pull Down	22442688
Intra	XRCC6	P12956	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	XRCC6	P12956	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	XRCC6	P12956	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	XRCC6	P12956	TERF2IP	Homo sapiens	Q9NYB0	Anti Tag CoIP	26496610
Intra	XRCC6	P12956	TCF7L2	Homo sapiens	Q9NQB0	Anti Tag CoIP	17283121
Intra	XRCC6	P12956	TCF7L2	Homo sapiens	Q9NQB0	Anti Bait CoIP	17283121
Intra	XRCC6	P12956	COIL	Homo sapiens	P38432	Competition Binding	21070772
Intra	XRCC6	P12956	COIL	Homo sapiens	P38432	Pull Down	21070772

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XRCC6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73846	Ku70-Ku80 Heterodimer Protein, Human (sf9, His)	P13010 (M1-I732)&P12956 (M1-D609)	≥ 90%, as determined by reducing SDS-PAGE.

XRCC6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80202	Ku70 Antibody (YA715)	WB, IHC-P	Human, Mouse
HY-P80736	Ku70 Antibody (YA319)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P80736A	Ku70 Antibody (YA319)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P85597	Ku70 Antibody (YA5289)	WB, ICC/IF, IP	Human, Monkey

Related Diseases

Diseases	Alias
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Lig4 Syndrome	Dna Ligase Iv Deficiency Ligase 4 Syndrome LIG4S
Epidemic Typhus	Typhus Typhus Fever Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii Murine Typhus Classical Typhus Endemic Flea-Borne Typhus Endemic Typhus Fever Epidemic Louse-Borne Typhus Famine Fever Flea-Borne Typhus Jail Fever Louse-Borne Typhus Mexican Typhus Shop Typhus Urban Typhus Brill-Zinsser Disease Endemic Typhus Sylvatic Typhus Epidemic Typhus European Typhus Exanthematic Typhus Fever Exanthematous Typhus Flea Typhus Flea-Borne Rickettsiosis Hospital Fever Louse-Borne [Epidemic] Typhus Louse-Borne Rickettsiosis Moscow Typhus Murine [Endemic] Typhus Petechial Fever Prison Fever Rat Flea Typhus Ship Fever Typhus Exanthematique Typhus, Endemic Flea-Borne Typhus, Epidemic Louse-Borne Typhus Group Rickettsial Disease Relapsing Fever Typhus Fever Nos Typhus Nos Epidemic Typhus Fever Louse-Borne Typhus Fever Classical Typhus Fever Louse-Borne Tabardillo Epidemic Typhus Fever Due To Rickettsia Prowazekii Endemic Murine Typhus Flea-Borne Typhus Fever Murine Endemic Flea Typhus Rat Typhus Typhus Due To Rickettsia Typhi Flea-Borne Tabardillo Rickettsia Typhi Rickettsiosis Mexican Fever Murine Flea-Borne Typhus Mooser Bodies Tsutsugamushi Fever Kedani Fever Mite-Borne Typhus Mite-Borne Typhus Due To Rickettsia Tsutsugamushi Scrub Typhus Tsutsugamushi Tsutsugamushi Disease Scrub Mite-Borne Typhus Sumatran Mite Fever Japanese River Fever Kedani Typhus Rickettsia Tsutsugamushi Rickettsiosis Sumatran Mite Typhus Tropical Typhus Japanese Typhus
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation	Severe Combined Immunodeficiency, Athabascan Type Severe Combined Immunodeficiency Due To Dclre1c Deficiency Rs-Scid Scid, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, With Sensitivity To Ionizing Radiation Scid Due To Artemis Deficiency Scid Due To Dclre1c Deficiency Scid, Athabascan Type Scid, Athabaskan Type Severe Combined Immunodeficiency Due To Artemis Deficiency Severe Combined Immunodeficiency, Athabaskan Type SCIDA Severe Combined Immunodeficiency, Athabascan-Type Artemis Deficiency Severe Combined Immunodeficiency Athabaskan Type Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive With Sensitivity To Ionizing Radiation RSSCID Athabascan Scid Immunodeficiency, Severe Combined, Athabascan Type Severe Combined Immunodeficiency, Athabaskan-Type
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Brill-Zinsser Disease	Recrudescent Typhus Brill Disease Brill Zinsser Disease Brill'S Disease Latent Typhus Sporadic Typhus Typhus, Epidemic Louse-Borne Recrudescent Typhus Due To Rickettsia Prowazekii Recrudescent Typhus Fever Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii Recrudescent Brill Disease Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Xeroderma Pigmentosum, Complementation Group A	Xeroderma Pigmentosum Group A Xp1 Xeroderma Pigmentosum, Group A XPA Xeroderma Pigmentosum I Xeroderma Pigmentosum Complementation Group A Xp Group A Xp, Group A Xeroderma Pigmentosum 1 Xeroderma Pigmentosum, Type 1 XP-A
Endemic Typhus	Murine Typhus Cat Flea Rickettsiosis Fleaborne Typhus Rat-Flea Typhus Rickettsia Felis Spotted Fever Shop Typhus Toulon Typhus Urban Typhus Urban Typhus Of Malaya Flea-Borne Typhus Endemic Flea-Borne Typhus
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Autosomal Recessive Cerebellar Ataxia	Arca
Epilepsy, Idiopathic Generalized 2	EIG2 Epilepsy, Idiopathic Generalized, Susceptibility To, 2 Idiopathic Generalized Epilepsy 2 Epilepsy, Idiopathic Generalized Locus On Chromosome 14 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 14
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa 44	RP44 Retinitis Pigmentosa, Type 44
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15901	XRCC6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19756	Xrcc6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26253	Xrcc6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	XRCC6	VGNC	VGNC:48470
Rattus norvegicus	XRCC6	RGD	RGD:2643
Macaca mulatta	XRCC6	VGNC	VGNC:98471
Felis catus	XRCC6	VGNC	VGNC:67121
Bos taurus	XRCC6	VGNC	VGNC:37007
Mus musculus	XRCC6	MGD	MGI:95606
Others	XRCC6	NCBI