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ARAP1 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Gene

Also Known as CENTD2; cnt-d2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116985

About ARAP1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,685,069-72,752,408 (from NCBI)

This gene has 21 transcripts (splice variants), 210 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 32.0), appendix (RPKM 25.3) and 25 other tissues.

Summary

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

ARAP1 Products (4)

mRNA	Protein	Name
NM_001040118.3	NP_001035207.1	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform c
NM_001135190.2	NP_001128662.1	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform d
NM_001369489.1	NP_001356418.1	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform e
NM_015242.5	NP_056057.2	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	11804590	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	11804589	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15607035	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	11804590	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	11804590	GOA
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	11804590	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	11804590	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11804590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARAP1 Protein Structure

SAM_1

ArfGap

RhoGAP

0
300
600
900
1200
1450 a.a.

Protein Preferred Names	Protein Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1	ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1

ARAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARAP1	Q96P48	XRCC6	Homo sapiens	P12956	Y2H Pooling	16169070
Cross	ARAP1	Q96P48	P27958-PRO_0000037576	Hepatitis C virus	P27958-PRO_0000037576	Pull Down	15607035

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wolfram Syndrome 2	WFS2
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00887	ARAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARAP1	VGNC	VGNC:59862
Bos taurus	ARAP1	VGNC	VGNC:106641
Rattus norvegicus	ARAP1	RGD	RGD:1310385
Canis familiaris	ARAP1	VGNC	VGNC:38025
Mus musculus	ARAP1	MGD	MGI:1916960
Macaca mulatta	ARAP1	VGNC	VGNC:69844
Others	ARAP1	NCBI