ARAP1 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Gene

Homo sapiens

Also known as CENTD2; cnt-d2

Gene ID: 116985 | Gene type: protein coding

About ARAP1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,685,069-72,752,408 (from NCBI)

This gene has 21 transcripts (splice variants), 210 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 32.0), appendix (RPKM 25.3) and 25 other tissues.

Summary

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

ARAP1 Products(4)

mRNA	Protein	Name
NM_001040118.3	NP_001035207.1	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform c
NM_001135190.2	NP_001128662.1	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform d
NM_001369489.1	NP_001356418.1	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform e
NM_015242.5	NP_056057.2	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform a

ARAP1 Protein Structure

SAM_1

ArfGap

RhoGAP

0
300
600
900
1200
1450 a.a.

Protein Preferred Names

Protein Names

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1

Related Diseases

Diseases

Alias

Wolfram Syndrome 2

WFS2

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00887	ARAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARAP1	VGNC	VGNC:59862
Bos taurus	ARAP1	VGNC	VGNC:106641
Rattus norvegicus	ARAP1	RGD	RGD:1310385
Canis familiaris	ARAP1	VGNC	VGNC:38025
Mus musculus	ARAP1	MGD	MGI:1916960
Macaca mulatta	ARAP1	VGNC	VGNC:69844

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