WRN - WRN RecQ like helicase Gene

Also Known as RECQ3; RECQL2; RECQL3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7486

About WRN

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:31,033,810-31,176,138 (from NCBI)

This gene has 6 transcripts (splice variants), 152 orthologues, 4 paralogues and is associated with 91 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.0), endometrium (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

WRN Products (1)

mRNA	Protein	Name
NM_000553.6	NP_000544.2	bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-5' DNA helicase activity	IDA IDA: Inferred from direct assay	17715146	GOA
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	10783163	GOA
enables 3'-flap-structured DNA binding	IDA IDA: Inferred from direct assay	26420422	GOA
enables 8-hydroxy-2'-deoxyguanosine DNA binding	IDA IDA: Inferred from direct assay	19734539	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	10373438	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	9288107	GOA
enables DNA helicase activity	IDA IDA: Inferred from direct assay	9288107	GOA
enables DNA helicase activity	IMP IMP: Inferred from mutant phenotype	10871376	GOA
enables G-quadruplex DNA binding	IDA IDA: Inferred from direct assay	11433031	GOA
enables MutLalpha complex binding	IDA IDA: Inferred from direct assay	17715146	GOA
enables Y-form DNA binding	IDA IDA: Inferred from direct assay	11735402	GOA
enables bubble DNA binding	IDA IDA: Inferred from direct assay	11433031	GOA
enables exonuclease activity	IDA IDA: Inferred from direct assay	12944467	GOA
enables exonuclease activity	IMP IMP: Inferred from mutant phenotype	15200954	GOA
enables forked DNA-dependent helicase activity	IDA IDA: Inferred from direct assay	11735402	GOA
enables four-way junction DNA binding	IDA IDA: Inferred from direct assay	11735402	GOA
enables four-way junction helicase activity	IDA IDA: Inferred from direct assay	11433031	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	16622405	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	16622405	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10373438	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10783163	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10783163	GOA
enables telomeric D-loop binding	IDA IDA: Inferred from direct assay	19734539	GOA
enables telomeric G-quadruplex DNA binding	IDA IDA: Inferred from direct assay	19734539	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	18203716	GOA
involved in DNA duplex unwinding	IDA IDA: Inferred from direct assay	11735402	GOA
involved in DNA metabolic process	IDA IDA: Inferred from direct assay	16622405	GOA
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	12882351	GOA
involved in DNA synthesis involved in DNA repair	IDA IDA: Inferred from direct assay	17563354	GOA
involved in G-quadruplex DNA unwinding	IDA IDA: Inferred from direct assay	11735402	GOA
involved in base-excision repair	IDA IDA: Inferred from direct assay	17611195	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	21639834	GOA
acts upstream of or within cellular response to starvation	IDA IDA: Inferred from direct assay	11420665	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	18212065	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	21639834	GOA
involved in positive regulation of hydrolase activity	IDA IDA: Inferred from direct assay	17611195	GOA
involved in positive regulation of strand invasion	IDA IDA: Inferred from direct assay	26420422	GOA
acts upstream of or within protein localization to nucleolus	IDA IDA: Inferred from direct assay	11420665	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	17115688	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	12882351	GOA
involved in response to UV-C	IDA IDA: Inferred from direct assay	17563354	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	17611195	GOA
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	18212065	GOA
involved in telomeric D-loop disassembly	IDA IDA: Inferred from direct assay	15200954	GOA
involved in telomeric D-loop disassembly	IGI IGI: Inferred from genetic interaction	22039056	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	17498979	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	15200954	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9618508	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	11420665	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WRN Protein Structure

DNA_pol_A_exo1

DEAD

Helicase_C

RQC

HRDC

HTH_40

0
300
600
900
1200
1432 a.a.

Protein Preferred Names	Protein Names
bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN Werner syndrome ATP-dependent helicase	DNA helicase, RecQ-like type 3

Protein Preferred Names

Protein Names

bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Werner syndrome ATP-dependent helicase

DNA helicase, RecQ-like type 3

WRN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WRN	Q14191	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	18203716
Intra	WRN	Q14191	SIRT1	Homo sapiens	Q96EB6	Deacetylase Assay	18203716
Intra	WRN	Q14191	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	18203716
Intra	WRN	Q14191	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	14734561
Intra	WRN	Q14191	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	11328876
Intra	WRN	Q14191	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	10783163
Intra	WRN	Q14191	XRCC6	Homo sapiens	P12956	Affinity Chrom	10783163
Intra	WRN	Q14191	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	14734561
Intra	WRN	Q14191	PARP1	Homo sapiens	P09874	Anti Tag CoIP	14734561
Intra	WRN	Q14191	PARP1	Homo sapiens	P09874	Anti Bait CoIP	14596914
Intra	WRN	Q14191	PARP1	Homo sapiens	P09874	Anti Bait CoIP	14734561
Intra	WRN	Q14191	TP53	Homo sapiens	P04637	Far-WB	11427532
Intra	WRN	Q14191	TP53	Homo sapiens	P04637	IF	11427532
Intra	WRN	Q14191	TP53	Homo sapiens	P04637	ELISA	15735006
Intra	WRN	Q14191	BLM	Homo sapiens	P54132	IF	11919194
Intra	WRN	Q14191	BLM	Homo sapiens	P54132	Pull Down	11919194
Intra	WRN	Q14191	BLM	Homo sapiens	P54132	ELISA	11919194
Intra	WRN	Q14191	RPA1	Homo sapiens	P27694	Y2H	15965237
Intra	WRN	Q14191	RPA1	Homo sapiens	P27694	ELISA	15965237
Intra	WRN	Q14191	RPA1	Homo sapiens	P27694	Anti Bait CoIP	10373438
Intra	WRN	Q14191	RPA1	Homo sapiens	P27694	Pull Down	15965237
Intra	WRN	Q14191	RAD52	Homo sapiens	P43351	Y2H	12750383
Intra	WRN	Q14191	RAD52	Homo sapiens	P43351	Far-WB	12750383
Intra	WRN	Q14191	RAD52	Homo sapiens	P43351	CoIP	12750383
Intra	WRN	Q14191	RAD52	Homo sapiens	P43351	FRET	12750383
Intra	WRN	Q14191	TERF2	Homo sapiens	Q15554	Pull Down	12181313
Intra	WRN	Q14191	TERF2	Homo sapiens	Q15554	ELISA	12181313
Intra	WRN	Q14191	FEN1	Homo sapiens	P39748	Pull Down	11598021
Intra	WRN	Q14191	FEN1	Homo sapiens	P39748	Affinity Chrom	11598021
Intra	WRN	Q14191	FEN1	Homo sapiens	P39748	FRET	14657243
Intra	WRN	Q14191	FEN1	Homo sapiens	P39748	Anti Bait CoIP	11598021
Intra	WRN	Q14191	CBX5	Homo sapiens	P45973	Anti Tag CoIP	25931448
Intra	WRN	Q14191	CBX5	Homo sapiens	P45973	Anti Bait CoIP	25931448

Cross: Cross-species interaction Intra: Intraspecies interaction

WRN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82276	WRN Antibody (YA2021)	WB	Human

Related Diseases

Diseases	Alias
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Bloom Syndrome	BLM Bs Bls Bloom-Torre-Machacek Syndrome Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1 Mgrisce1 Congenital Telangiectatic Erythema Congenital Telangiectatic Erythema Syndrome Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability Bloom'S Syndrome Bsyn
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Rapadilino Syndrome	Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate Radial And Patellar Aplasia Radial And Patellar Hypoplasia RAPADILINOS
Rothmund-Thomson Syndrome, Type 2	Rothmund-Thomson Syndrome Rts RTS2 Poikiloderma Of Rothmund-Thomson Rothmund-Thomson Syndrome Type 2 Congenital Poikiloderma Poikiloderma Congenitale Poikiloderma Atrophicans And Cataract Poikiloderma Congenitale Of Rothmund-Thomson Poikiloderma Of Rothmund-Thomson Type 2 Rothmund-Thomson Syndrome 2 Erythrokeratodermia Variabilis
Aging
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Adermatoglyphia	ADERM Immigration Delay Disease Absence Of Fingerprints Adg Congenital Absence Of Fingerprints Isolated Congenital Adermatoglyphia Fingerprints, Absence Of Skin Abnormalities
Baller-Gerold Syndrome	BGS Craniosynostosis With Radial Defects Craniosynostosis-Radial Aplasia Syndrome Craniosynostosis Radial Aplasia Syndrome
Acute Generalized Exanthematous Pustulosis	Agep Pustular Drug Eruption Toxic Pustuloderma
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Progeroid Syndrome
Fanconi Anemia, Complementation Group J	Fanconi Anemia Complementation Group J FANCJ
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Xfe Progeroid Syndrome	Xpf-Ercc1 Progeroid Syndrome XFEPS
Diabetes Mellitus	Diabetes
Schimke Immunoosseous Dysplasia	Schimke Immuno-Osseous Dysplasia SIOD Immunoosseous Dysplasia, Schimke Type Schimke Syndrome Immunoosseous Dysplasia Schimke Type Spondyloepiphyseal Dysplasia - Nephrotic Syndrome Spondyloepiphyseal Dysplasia Nephrotic Syndrome Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Lens Disease	Lens Diseases
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Autosomal Recessive Cerebellar Ataxia	Arca
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-169422	GSK4418959	Inhibitor	99.07%	Phase 2
HY-148699	HRO761	Inhibitor	99.58%	Phase 1
HY-158116	VVD-214	Inhibitor	99.99%	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12342	ML216	Inhibitor	99.89%	Unkown
HY-110185	NSC 617145	Inhibitor	99.53%	Unkown
HY-162471	GSK_WRN3	Inhibitor	98.10%	Unkown
HY-163942	GSK_WRN4	Inhibitor	98.85%	Unkown
HY-156579	WRN inhibitor 3	Inhibitor	99.54%	Unkown
HY-156581	WRN inhibitor 5	Inhibitor	98.12%	Unkown
HY-160859	WRN inhibitor 8	Inhibitor	98.07%	Unkown
HY-148740	Werner syndrome RecQ helicase-IN-3	Inhibitor	99.94%	Unkown
HY-149887	H3B-968		98.22%	Unkown
HY-148741	Werner syndrome RecQ helicase-IN-4	Inhibitor	98.13%	Unkown
HY-128712	NCGC00029283	Inhibitor	98.88%	Unkown
HY-156580	WRN inhibitor 4	Inhibitor	99.40%	Unkown
HY-163941	GSK_WRN2		95.95%	Unkown
HY-153692	WRN inhibitor 1	Inhibitor	98.05%	Unkown
HY-153973	WRN inhibitor 2		99.60%	Unkown
HY-175750	MOMA-341	Inhibitor	/	Unkown
HY-148700	Werner syndrome RecQ helicase-IN-2	Inhibitor	99.32%	Unkown
HY-169422A	GSK4418959 (enantiomer)		95.0%	Unkown
HY-158025	Anticancer agent 198	Inhibitor	/	Unkown
HY-153692A	(R)-WRN inhibitor 1		/	Unkown
HY-157954	WRN inhibitor 6		/	Unkown
HY-161386	WRN inhibitor 7		/	Unkown
HY-163797	WRN inhibitor 10	Inhibitor	/	Unkown
HY-164852	WRN inhibitor 13		/	Unkown
HY-168583	WRN inhibitor 11	Inhibitor	/	Unkown
HY-168592	WRN inhibitor 12	Inhibitor	/	Unkown
HY-168933	KWR095	Inhibitor	/	Unkown
HY-168934	KWR137	Inhibitor	/	Unkown
HY-169414	WRN inhibitor 15		/	Unkown
HY-169423	WRN inhibitor 17	Inhibitor	/	Unkown
HY-169424	WRN inhibitor 18	Inhibitor	/	Unkown
HY-169928	WRN inhibitor 14	Inhibitor	/	Unkown
HY-174217	WRN-IN-19	Inhibitor	/	Unkown
HY-176727	WRN inhibitor 19	Inhibitor	/	Unkown
HY-176912	WRN-IN-22	Inhibitor	/	Unkown
HY-178474	WRN-IN-20		/	Unkown
HY-178991	WRN-IN-21	Inhibitor	/	Unkown
HY-179326	WRN-IN-23		/	Unkown
HY-181562	WRN-IN-24	Inhibitor	/	Unkown
HY-182313	WRN-IN-25	Inhibitor	/	Unkown
HY-182634	NCGC00063279	Inhibitor	/	Unkown
HY-183610	WRN-IN-26		/	Unkown
HY-184427	WRN-IN-27	Inhibitor	/	Unkown
HY-RS15847	WRN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16538	Wrn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22970	Wrn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WRN	VGNC	VGNC:56083
Bos taurus	WRN	VGNC	VGNC:59444
Rattus norvegicus	WRN	RGD	RGD:1564788
Felis catus	WRN	VGNC	VGNC:67090
Macaca mulatta	WRN	VGNC	VGNC:78803
Mus musculus	WRN	MGD	MGI:109635
Others	WRN	NCBI