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Cat. No.: HY-157954

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WRN inhibitor 6

WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression.

For research use only. We do not sell to patients.

Formula: C₂₉H₃₄O₅S
Molecular Weight:494.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

WRN inhibitor 6 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression^[1].

IC₅₀ & Target

IC₅₀:2.305 µM (WRN)^[1]

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SW-620	IC₅₀	16.58 μM Compound: 3ci	Cytotoxicity against human SW620 cells incubated for 3 days by CellTiter 96 Aqueous One Solution Proliferation Assay Cytotoxicity against human SW620 cells incubated for 3 days by CellTiter 96 Aqueous One Solution Proliferation Assay	[PMID: 38295487]

In Vitro

WRN inhibitor 6 (compound 3ci) (0-100 µM; 72 h) induces DNA damage and apoptotic cell death with IC₅₀s of 2.305, 16.58 µM for HCT116, SW620 cells, respectively^[1].
WRN inhibitor 6 (0, 2.5, 5, 10 µM; 3, 27 h) increases the expression of p-p53, P-Chk2, γH2AX expression in a dose-dependent manner in HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HCT116, SW620 cells
Concentration:

0-100 µM
Incubation Time:

72 h
Result:

Induced cell death with IC₅₀s of 2.305, 16.58 µM for HCT116, SW620 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0, 2.5, 5, 10 µM
Incubation Time:

3, 27 h
Result:

Increased p-p53, P-Chk2, γH2AX expression in a dose-dependent manner.

In Vivo

WRN inhibitor 6 (20 mg/kg for p.o.; 5 mg/kg for i.v.) shows low oral availability with F of 11.43% and a short half-life of 0.17 h for IV in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 494.64
Formula C₂₉H₃₄O₅S
SMILES

CCOC1=CC=C(C=C1)C2=CC=C(S2)C(C3=C(CC(C)(CC3=O)C)O)C4=C(CC(C)(CC4=O)C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang H, et al. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability. Bioorg Med Chem. 2024 Feb 15;100:117588. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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WRN inhibitor 6

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WRN inhibitor 6 Related Classifications

HY-157954 Related Classifications