2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. WRN inhibitor 6

WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression.

For research use only. We do not sell to patients.

WRN inhibitor 6 Chemical Structure

WRN inhibitor 6 Chemical Structure

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WRN inhibitor 6 Related Antibodies

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Description

WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression[1].

IC50 & Target

IC50:2.305 µM (WRN)[1]
In Vitro

WRN inhibitor 6 (compound 3ci) (0-100 µM; 72 h) induces DNA damage and apoptotic cell death with IC50s of 2.305, 16.58 µM for HCT116, SW620 cells, respectively[1].
WRN inhibitor 6 (0, 2.5, 5, 10 µM; 3, 27 h) increases the expression of p-p53, P-Chk2, γH2AX expression in a dose-dependent manner in HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WRN inhibitor 6 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HCT116, SW620 cells
Concentration: 0-100 µM
Incubation Time: 72 h
Result: Induced cell death with IC50s of 2.305, 16.58 µM for HCT116, SW620 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0, 2.5, 5, 10 µM
Incubation Time: 3, 27 h
Result: Increased p-p53, P-Chk2, γH2AX expression in a dose-dependent manner.
In Vivo

WRN inhibitor 6 (20 mg/kg for p.o.; 5 mg/kg for i.v.) shows low oral availability with F of 11.43% and a short half-life of 0.17 h for IV in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

494.64

Formula

C29H34O5S
SMILES

CCOC1=CC=C(C=C1)C2=CC=C(S2)C(C3=C(CC(C)(CC3=O)C)O)C4=C(CC(C)(CC4=O)C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WRN inhibitor 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WRN inhibitor 6WRN inhibitor6WRN inhibitor-6DNA/RNA SynthesisApoptosisHCT116SW620 cellsp-p53P-Chk2γH2AXapoptosisInhibitorinhibitorinhibit

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