(3S,17S)-FD-895
(3S,17S)-FD-895 a FD-895 (HY-114461) analogue, is a spliceosome modulator. (3S,17S)-FD-895 inhibits cancer cell growth and exhibits gene-selective splice modulatory activity. (3S,17S)-FD-895 can be used for the research of colorectal carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 2598242-04-5
- Formula: C31H50O9
- Molecular Weight:566.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| HCT-116 | GI50 |
143 nM
Compound: 1g
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Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
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[PMID: 37155693] |
(3S,17S)-FD-895 (Compound 1g) (72 h) inhibits the growth of HCT116 colorectal carcinoma cells with a GI50 of 143 nM after 72 h of treatment[1].
(3S,17S)-FD-895 (2.6 μM; 4 h) modulates RNA splicing in HCT116 colorectal carcinoma cells after 4 h of treatment at 6 μM, inducing intron retention in select splicing-related and stress response genes and downregulating SF2 expression[1].
(3S,17S)-FD-895 (100-500 nM; 24 h) modulates RNA splicing in HCT116 colorectal carcinoma cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 colorectal carcinoma cells
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Concentration:2.6 μM
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Incubation Time:4 h
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Result:Induced intron retention in DNAJB1, SF3A1, and SF3B2.
Downregulated the expression of SF2.
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Cell Line:HCT116 colorectal carcinoma cells
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Concentration:100, 250, 500 nM
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Incubation Time:24 h
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Result:Showed reduced intron retention in DNAJB1, SF3B2, and SF3A1, and reduced ability to inhibit SF2 expression.
Displayed comparable intron retention in SF3A3 and reduced PLK-1 expression.
Induced intron retention in SF3A1 and altered AURKA expression.
Chemical Information
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CAS No. 2598242-04-5
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Molecular Weight 566.72
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Formula C31H50O9
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SMILES
CC[C@H](OC)[C@H]([C@]1([H])[C@@](O1)([H])[C@@H](O)[C@H](C)/C=C/C=C([C@@H]2[C@H](/C=C/[C@@H]([C@](O)(CC[C@@H](CC(O2)=O)O)C)OC(C)=O)C)\C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(3S,17S)-FD-895 Related Classifications
HY-114461B Related Classifications
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