2. Others Cell Cycle/DNA Damage
  3. Drug Derivative DNA/RNA Synthesis
  4. (3S,17S)-FD-895

(3S,17S)-FD-895 a FD-895 (HY-114461) analogue, is a spliceosome modulator. (3S,17S)-FD-895 inhibits cancer cell growth and exhibits gene-selective splice modulatory activity. (3S,17S)-FD-895 can be used for the research of colorectal carcinoma.

For research use only. We do not sell to patients.

(3S,17S)-FD-895

(3S,17S)-FD-895 Chemical Structure

CAS No. : 2598242-04-5

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(3S,17S)-FD-895 Related Antibodies

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Description

(3S,17S)-FD-895 a FD-895 (HY-114461) analogue, is a spliceosome modulator. (3S,17S)-FD-895 inhibits cancer cell growth and exhibits gene-selective splice modulatory activity. (3S,17S)-FD-895 can be used for the research of colorectal carcinoma[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 GI50
143 nM
Compound: 1g
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
[PMID: 37155693]
In Vitro

(3S,17S)-FD-895 (Compound 1g) (72 h) inhibits the growth of HCT116 colorectal carcinoma cells with a GI50 of 143 nM after 72 h of treatment[1].
(3S,17S)-FD-895 (2.6 μM; 4 h) modulates RNA splicing in HCT116 colorectal carcinoma cells after 4 h of treatment at 6 μM, inducing intron retention in select splicing-related and stress response genes and downregulating SF2 expression[1].
(3S,17S)-FD-895 (100-500 nM; 24 h) modulates RNA splicing in HCT116 colorectal carcinoma cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(3S,17S)-FD-895 Related Antibodies

Real Time qPCR[1]

Cell Line: HCT116 colorectal carcinoma cells
Concentration: 2.6 μM
Incubation Time: 4 h
Result: Induced intron retention in DNAJB1, SF3A1, and SF3B2.
Downregulated the expression of SF2.

Real Time qPCR[1]

Cell Line: HCT116 colorectal carcinoma cells
Concentration: 100, 250, 500 nM
Incubation Time: 24 h
Result: Showed reduced intron retention in DNAJB1, SF3B2, and SF3A1, and reduced ability to inhibit SF2 expression.
Displayed comparable intron retention in SF3A3 and reduced PLK-1 expression.
Induced intron retention in SF3A1 and altered AURKA expression.
Molecular Weight

566.72

Formula

C31H50O9
CAS No.
SMILES

CC[C@H](OC)[C@H]([C@]1([H])[C@@](O1)([H])[C@@H](O)[C@H](C)/C=C/C=C([C@@H]2[C@H](/C=C/[C@@H]([C@](O)(CC[C@@H](CC(O2)=O)O)C)OC(C)=O)C)\C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(3S,17S)-FD-895 Related Classifications

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Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(3S,17S)-FD-8952598242-04-5Drug DerivativeDNA/RNA SynthesisDrug derivativeMCL-1LPLK-1SF3B2SF3A1DNAJB1colorectal carcinoma cellsHCT116 colorectal carcinoma cellsSF2SF3A3AURKAInhibitorinhibitorinhibit

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