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Art. -Nr.: HY-114461B

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(3S,17S)-FD-895

(3S,17S)-FD-895 a FD-895 (HY-114461) analogue, is a spliceosome modulator. (3S,17S)-FD-895 inhibits cancer cell growth and exhibits gene-selective splice modulatory activity. (3S,17S)-FD-895 can be used for the research of colorectal carcinoma.

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CAS. Nr.: 2598242-04-5
Formel: C₃₁H₅₀O₉
Molecular Weight:566.72

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(3S,17S)-FD-895 Chemical Structure

CAS. Nr.: 2598242-04-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	143 nM Compound: 1g	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay	[PMID: 37155693]

In Vitro

(3S,17S)-FD-895 (Compound 1g) (72 h) inhibits the growth of HCT116 colorectal carcinoma cells with a GI₅₀ of 143 nM after 72 h of treatment^[1].
(3S,17S)-FD-895 (2.6 μM; 4 h) modulates RNA splicing in HCT116 colorectal carcinoma cells after 4 h of treatment at 6 μM, inducing intron retention in select splicing-related and stress response genes and downregulating SF2 expression^[1].
(3S,17S)-FD-895 (100-500 nM; 24 h) modulates RNA splicing in HCT116 colorectal carcinoma cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

HCT116 colorectal carcinoma cells
Concentration:

2.6 μM
Incubation Time:

4 h
Result:

Induced intron retention in DNAJB1, SF3A1, and SF3B2.
Downregulated the expression of SF2.

Real Time qPCR^[1]

Cell Line:

HCT116 colorectal carcinoma cells
Concentration:

100, 250, 500 nM
Incubation Time:

24 h
Result:

Showed reduced intron retention in DNAJB1, SF3B2, and SF3A1, and reduced ability to inhibit SF2 expression.
Displayed comparable intron retention in SF3A3 and reduced PLK-1 expression.
Induced intron retention in SF3A1 and altered AURKA expression.

Chemical Information

CAS. Nr. 2598242-04-5
Molecular Weight 566.72
Formel C₃₁H₅₀O₉
SMILES

CC[C@H](OC)[C@H]([C@]1([H])[C@@](O1)([H])[C@@H](O)[C@H](C)/C=C/C=C([C@@H]2[C@H](/C=C/[C@@H]([C@](O)(CC[C@@H](CC(O2)=O)O)C)OC(C)=O)C)\C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chan WC, et al. Stereochemical Control of Splice Modulation in FD-895 Analogues. J Med Chem. 2023;66(10):6577-6590. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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(3S,17S)-FD-895

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