FD-895
FD-895 is a spliceosome modulator derived from a polyketide natural product, targeting the SF3b subunit of the spliceosome. FD-895 possesses core biological activities for regulating RNA splicing (intron retention, alternative splicing) and inducing apoptosis of cancer cells. FD-895 can be used for the research of cancer, such as chronic lymphocytic leukemia (CLL).
For research use only. We do not sell to patients.
- CAS No.: 147025-57-8
- Formula: C31H50O9
- Molecular Weight:566.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
23.5 nM
Compound: 1a, FD-895
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Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
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[PMID: 23919277] |
Chemical Information
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CAS No. 147025-57-8
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Molecular Weight 566.72
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Formula C31H50O9
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SMILES
CC[C@H](OC)[C@H]([C@]1([H])[C@]([C@H](O)[C@H](C)/C=C/C=C([C@@H](O2)[C@H](/C=C/[C@@H]([C@](O)(CC[C@@H](O)CC2=O)C)OC(C)=O)C)\C)([H])O1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FD-895 Related Classifications
HY-114461 Related Classifications
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