1. Membrane Transporter/Ion Channel
  2. Potassium Channel

4-Aminopyridine (Synonyms: 4-AP; 4-Pyridinamine; Fampridine)

Cat. No.: HY-B0604 Purity: 99.97%
Handling Instructions

4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.

For research use only. We do not sell to patients.

4-Aminopyridine Chemical Structure

4-Aminopyridine Chemical Structure

CAS No. : 504-24-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 84 In-stock
Estimated Time of Arrival: December 31
5 g USD 76 In-stock
Estimated Time of Arrival: December 31
10 g USD 115 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Description

4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. Target: Potassium Channel 4-Aminopyridine(4AP) is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. 4AP strongly potentiates transmitter release from the unmyelinated terminals of rat motor nerves, and the possibility arose that demyelinated axon membrane, which can conduct impulses continuously like an unmyelinated fibre, might further resemble its unmyelinated terminals by responding to 4AP. In testing this hypothesis [1]. 4-AP blocked channels from the cytosolic face. 4-AP can both enhance and block Kv1.5 current and suggest that 4-AP can bind with different affinities to more than one site on Kv1.5 channels [2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 10.6259 mL 53.1293 mL 106.2586 mL
5 mM 2.1252 mL 10.6259 mL 21.2517 mL
10 mM 1.0626 mL 5.3129 mL 10.6259 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

94.11

Formula

C₅H₆N₂

CAS No.

504-24-5

SMILES

NC1=CC=NC=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.97%

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Product Name:
4-Aminopyridine
Cat. No.:
HY-B0604
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4-Aminopyridine

Cat. No.: HY-B0604