1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. AZ-1355

AZ-1355 

Cat. No.: HY-101692
Handling Instructions

AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.

For research use only. We do not sell to patients.

AZ-1355 Chemical Structure

AZ-1355 Chemical Structure

CAS No. : 75451-07-9

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Description

AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.

IC50 & Target[1]

Prostaglandin I2

 

Thromboxane A2

 

In Vivo

AZ-1355 (50 mg/kg) significantly reduces serum TG and the 100 mg/kg dose results in serum TC and TG reduction in rat. AZ-1355 (100 mg/kg) reduces total liver TC in rats fed CE-2, and the 50 mg/kg dose reduces hepatic TC in rats fed the high fat diet on both bases, and it also reduces the total hepatic TG of the CE-2 fed rats. AZ-1355 (150 mg/kg) reproducibly lowers serum total cholesterol (TC) in the Triton hyperlipidemic mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

299.32

Formula

C₁₇H₁₇NO₄

CAS No.

75451-07-9

SMILES

O=C(C1=CC=C2OC3=C(OC)C=CC=C3CNC2=C1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Mice[1]
Male mice, strain ddY, 6 weeks old are used in the assay. The mice are fasted overnight and then Triton WR-1399 (500 mg/kg) is intravenously injected. Immediately and 8 h after the injection, AZ-1366 or clofibrate (both 150 mg/kg, each) are given to the mice orally. The control mice receive the vehicle, 1% aqueous methycellulose. The mice are maintained for 24 h on drinking water only and then the blood is withdrawn from the heart.
Rats[1]
Male rats, strain Sprague-Dawley, 6 weeks old are used in the assay. A total of 56 rats are randomly assigned to 2 equal groups. One group is fed the CE-2 diet and the other the high fat diet. Each group is further subdivided into 4 equal groups (n=7). The rats in the first subgroup receives the vehicle, 5% aqueous gum arabic solution, orally (1 ml 100 g body weight). The second sub-group receives clofibrate (100 mg/kg daily), and the third and the fourth receive AZ-1355 in daily doses of 50 and 100 mg/kg, respectively. The drug is administered once a day for 4 consecutive weeks. Body weights are monitored daily. There is no difference in weight gains between the treated and corresponding control groups.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

AZ-1355AZ1355AZ 1355Prostaglandin ReceptorInhibitorinhibitorinhibit

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AZ-1355
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