1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Coproporphyrin III

Coproporphyrin III (Synonyms: Zincphyrin)

Cat. No.: HY-101398 Purity: 99.49%
Handling Instructions

Coproporphyrin III is a porphyrin derivative.

For research use only. We do not sell to patients.

Coproporphyrin III Chemical Structure

Coproporphyrin III Chemical Structure

CAS No. : 14643-66-4

Size Price Stock Quantity
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 324 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Coproporphyrin III is a porphyrin derivative.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Coproporphyrin III methyl ester is repeatedly isolated in considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease[1]. Primary cultures of chick embryo hepatocytes have been used to study the mechanism by which chemicals cause accumulation of intermediates of the heme synthetic pathway. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), addition of insulin causes a striking increase in accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolishes the uroporphyrin I accumulation and increases coproporphyrin III[2].

In Vivo

Urinary DMA and porphyrin profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control[3].

Molecular Weight

654.71

Formula

C₃₆H₃₈N₄O₈

CAS No.

14643-66-4

SMILES

O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(CCC(O)=O)C4=C\C5=N/C(C(CCC(O)=O)=C5C)=C\C(N2)=C1C)=N/3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (127.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5274 mL 7.6370 mL 15.2739 mL
5 mM 0.3055 mL 1.5274 mL 3.0548 mL
10 mM 0.1527 mL 0.7637 mL 1.5274 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.49%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Coproporphyrin IIIZincphyrinEndogenous MetaboliteInhibitorinhibitorinhibit

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Product Name:
Coproporphyrin III
Cat. No.:
HY-101398
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