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Fosphenytoin disodium 

Cat. No.: HY-B1657A Purity: >98.0%
Handling Instructions

Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.

For research use only. We do not sell to patients.

Fosphenytoin disodium Chemical Structure

Fosphenytoin disodium Chemical Structure

CAS No. : 92134-98-0

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
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10 mg USD 84 In-stock
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25 mg USD 168 In-stock
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50 mg USD 228 In-stock
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100 mg USD 348 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.

In Vivo

Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2].

Clinical Trial
Molecular Weight

406.24

Formula

C₁₆H₁₃N₂Na₂O₆P

CAS No.

92134-98-0

SMILES

O=C1N(COP([O-])([O-])=O)C(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O.[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (246.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4616 mL 12.3080 mL 24.6160 mL
5 mM 0.4923 mL 2.4616 mL 4.9232 mL
10 mM 0.2462 mL 1.2308 mL 2.4616 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

A total of four groups of rats, including normal (n=2), sham operated (n=2), ischemia with saline-treated (n=2), and ischemia with fosphenytoin-treated (n=2), are studied. Postischemic rats in saline-treated and fosphenytoin-treated groups receive a single i.m. injection of saline or fosphenytoin (30 mg/kg), respectively, in the right hind limb 5 minutes after resuscitation. Sham-operated animals are treated similarly except for chest compression. All rats are killed on the 7th postischemic day by decapitation. Brains are immediately removed, bisected longitudinally, and immersed in 4% buffered neutral formaldehyde containing 0.25% glutaraldehyde for a minimum of 2 days at 4°C. Portions of the brain containing the dorsal hippocampus are coronally sectioned with a vibratome at 40 μm. With the aid of a dissecting microscope, rectangular blocks of about 1 mm2 in size encompassing the mid-CA1 region from sections that approximate Bregma -3.6 are dissected, postfixed in 2% osmium tetroxide, and dehydrated in ascending concentrations of ethanol before being embedded in Araldite 502. Sections of polymerized blocks 1 μm thick are cut and toluidine blue stained for light microscopic examination.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Fosphenytoin disodium
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