92134-98-0
Chemical Structure
Fosphenytoin disodium
- CAS No.: 92134-98-0
- Formula:C16H13N2Na2O6P
- Molecular Weight:406.24
IUPAC Name: sodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
InChIKey: GQPXYJNXTAFDLT-UHFFFAOYSA-L
SMILES: O=C1N(COP(O[Na])(O[Na])=O)C(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O
Biological Activity: Fosphenytoin disodium is a prodrug of Phenytoin (HY-B0448). Fosphenytoin disodium can be converted to Phenytoin in vivo, which blocks voltage-gated sodium channels in a voltage- and use-dependent manner, prolonging inactivation and slowing recovery. Fosphenytoin disodium enhances GABA responses and, at higher concentrations, mildly modulates calcium channels and increases sodium-potassium ATPase activity. Fosphenytoin disodium raises the afterdischarge threshold, reduces the severity and duration of seizures, alleviates pain-like behavior, and protects hippocampal pyramidal neurons after ischemia without altering GFAP immunoreactivity. Fosphenytoin disodium can be used in research on acute herpes zoster pain, epilepsy, and cerebral ischemia[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Fosphenytoin disodium | 99.91% | Fosphenytoin disodium is a prodrug of Phenytoin (HY-B0448). Fosphenytoin disodium can be converted to Phenytoin in vivo, which blocks voltage-gated sodium channels in a voltage- and use-dependent manner, prolonging inactivation and slowing recovery. Fosphenytoin disodium enhances GABA responses and, at higher concentrations, mildly modulates calcium channels and increases sodium-potassium ATPase activity. Fosphenytoin disodium raises the afterdischarge threshold, reduces the severity and duration of seizures, alleviates pain-like behavior, and protects hippocampal pyramidal neurons after ischemia without altering GFAP immunoreactivity. Fosphenytoin disodium can be used in research on acute herpes zoster pain, epilepsy, and cerebral ischemia. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fosphenytoin disodium (Standard) | ≥98% | Fosphenytoin (disodium) (Standard) is the analytical standard of Fosphenytoin (disodium) (HY-B1657A). This product is intended for research and analytical applications. Fosphenytoin disodium is a prodrug of Phenytoin (HY-B0448). Fosphenytoin disodium can be converted to Phenytoin in vivo, which blocks voltage-gated sodium channels in a voltage- and use-dependent manner, prolonging inactivation and slowing recovery. Fosphenytoin disodium enhances GABA responses and, at higher concentrations, mildly modulates calcium channels and increases sodium-potassium ATPase activity. Fosphenytoin disodium raises the afterdischarge threshold, reduces the severity and duration of seizures, alleviates pain-like behavior, and protects hippocampal pyramidal neurons after ischemia without altering GFAP immunoreactivity. Fosphenytoin disodium can be used in research on acute herpes zoster pain, epilepsy, and cerebral ischemia. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fosphenytoin-d10 disodium | Fosphenytoin-d10 disodium is the deuterated-labeled Fosphenytoin (disodium) (HY-B1657A). Fosphenytoin disodium is a prodrug of Phenytoin (HY-B0448). Fosphenytoin disodium can be converted to Phenytoin in vivo, which blocks voltage-gated sodium channels in a voltage- and use-dependent manner, prolonging inactivation and slowing recovery. Fosphenytoin disodium enhances GABA responses and, at higher concentrations, mildly modulates calcium channels and increases sodium-potassium ATPase activity. Fosphenytoin disodium raises the afterdischarge threshold, reduces the severity and duration of seizures, alleviates pain-like behavior, and protects hippocampal pyramidal neurons after ischemia without altering GFAP immunoreactivity. Fosphenytoin disodium can be used in research on acute herpes zoster pain, epilepsy, and cerebral ischemia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.85
HY-B1657Fosphenytoin -
Similarity Score 0.62
HY-B0448Phenytoin -
Similarity Score 0.62
HY-B0448S1Phenytoin-15N2,13C -
Similarity Score 0.57
HY-B0448APhenytoin sodium -
Similarity Score 0.57
HY-1167103-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone -
Similarity Score 0.56
HY-118490T-2000 -
Similarity Score 0.56
HY-137258(±)-N-3-Benzylnirvanol -
Similarity Score 0.56
HY-137258A(R)-N-3-Benzylnirvanol -
Similarity Score 0.56
HY-W013268(S)-(+)-N-3-Benzylnirvanol -
Explore the MedChemAI to find more analogs
References
- [1]. Varia SA, et al. Phenytoin prodrugs III: water-soluble prodrugs for oral and/or parenteral use. J Pharm Sci. 1984;73(8):1068-1073. [Content Brief]
- [2]. Takasaki I, et al. Fosphenytoin Alleviates Herpes Simplex Virus Infection-Induced Provoked and Spontaneous Pain-Like Behaviors in Mice. Biol Pharm Bull. 2022 Mar 1;45(3):360-363. [Content Brief]
- [3]. Aleyadeh R, et al. Fosphenytoin. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. [Content Brief]
- [4]. Löscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30(1):69-76. [Content Brief]
- [5]. Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien). 1998;140(2):175-80. [Content Brief]
