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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
L74
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "L74" in MCE Product Catalog:
17
17 Publications Verification
Synonyms: DMP 266; EFV; L-743726
12
Target:
Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
11
11 Cited Publications
Cat. No.: HY-17006
CAS No.: 179463-17-3
Synonyms: MK-0991 diacetate; L-743872 diacetate
Target:
Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
11
Target:
Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
3
3 Cited Publications
Target:
Research Areas:
L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
3
3 Cited Publications
Target:
Research Areas:
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
2
2 Cited Publications
Target:
Research Areas:
L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively .
1
1 Cited Publications
Target:
Research Areas:
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases .
Cat. No.: HY-13625R
CAS No.: 153773-82-1
Synonyms: L-749345 (Standard); MK-826 (Standard)
Target:
Ertapenem sodium (Standard) is the analytical standard of Ertapenem sodium. This product is intended for research and analytical applications. Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].
Target:
Research Areas:
L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC90 of 4.3 μM for vRNP activity in HEK293T cells .
Cat. No.: HY-118944
CAS No.: 244192-93-6
Target:
Research Areas:
L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes .
Cat. No.: HY-116428
CAS No.: 160141-09-3
Research Areas:
L-744832 is a farnesyl transferase inhibitor. L-744832 effectively inhibits the farnesylation of H-Ras and N-Ras, but has little effect on K-Ras treatment. L-744832 not only directly targets the oncogenic pathway by inhibiting Ras farnesylation, but also enhances radiosensitivity by restoring TGF-β signaling through epigenetic reprogramming. L-744832 can induce cell cycle arrest and apoptosis. L-744832 can be used in combination therapy studies for Ras-driven tumors such as pancreatic cancer .
Cat. No.: HY-17006S
Synonyms: MK-0991-d4 diacetate; L-743872-d4 diacetate
Cat. No.: HY-119095
CAS No.: 187724-85-2
Target:
Research Areas:
L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Ki s of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively .
Cat. No.: HY-14325R
CAS No.: 158985-00-3
Target:
Research Areas:
L-745870 (Standard) is the analytical standard of L-745870. This product is intended for research and analytical applications. L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
Cat. No.: HY-17006R
CAS No.: 179463-17-3
Synonyms: MK-0991 diacetate (Standard); L-743872 diacetate (Standard)
Target:
Caspofungin (diacetate) (Standard) is the analytical standard of Caspofungin (diacetate). This product is intended for research and analytical applications. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
Cat. No.: HY-10572R
CAS No.: 154598-52-4
Synonyms: DMP 266 (Standard); EFV (Standard); L-743726 (Standard)
Category:
Cat. No.: HY-10572S1
CAS No.: 1261394-62-0
Synonyms: DMP 266-13C6; EFV-13C6; L-743726-13C6
Cat. No.: HY-116970
CAS No.: 159183-70-7
Target:
Research Areas:
L-749372 is a selective partial agonist beta 3 adrenergic receptor (EC50= 3.6 nM) .
Cat. No.: HY-117527
CAS No.: 159182-18-0
Target:
Research Areas:
L742791 is a β3-AR agonist. L742791 elicits lipolytic response in isolated nonhuman primate adipocytes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
