187724-85-2
Chemical Structure
L-741671
- CAS No.: 187724-85-2
- Formula:C23H22F6N4O2
- Molecular Weight:500.44
IUPAC Name: 5-(((2R,3R)-3-((3,5-bis(trifluoromethyl)benzyl)oxy)-2-phenylpiperidin-1-yl)methyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
InChIKey: ZUWHBRRBKKTMQO-UYAOXDASSA-N
SMILES: O=C1NNC(CN2[C@@H]([C@@H](CCC2)OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=CC=CC=C4)=N1
Biological Activity: L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively[1].
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L-741671 | L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively. | |||||||||||||||||||||
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Keywords