244192-93-6
Chemical Structure
L-748328
- CAS No.: 244192-93-6
- Formula:C23H27N3O6S2
- Molecular Weight:505.61
IUPAC Name: (S)-N-(4-(2-((2-hydroxy-3-(3-sulfamoylphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide
InChIKey: CVPJSQZQNBKALR-FQEVSTJZSA-N
SMILES: O=S(C1=CC=CC(OC[C@H](CNCCC2=CC=C(C=C2)NS(=O)(C3=CC=CC=C3)=O)O)=C1)(N)=O
Biological Activity: L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes[1].
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L-748328 | L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. | |||||||||||||||||||||
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Keywords
