1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. MK-2461

MK-2461 

Cat. No.: HY-50703 Purity: 99.92%
Handling Instructions

MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met with a mean IC50 of 2.5 nM.

For research use only. We do not sell to patients.

MK-2461 Chemical Structure

MK-2461 Chemical Structure

CAS No. : 917879-39-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 249 In-stock
Estimated Time of Arrival: December 31
2 mg USD 144 In-stock
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
25 mg USD 840 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met with a mean IC50 of 2.5 nM. IC50 value: 2.5 nM [1] Target: c-Met in vitro: MK-2461 inhibits the kinase activity of human c-Met with a mean IC50 of 2.5 nM in the presence of 50 μM ATP. Ron (IC50 = 7 nM) and Flt1 (IC50 = 10 nM) are inhibited by MK-2461 with similar potencies to c-Met (IC50 = 2.5 nM), whereas nine other kinases, including FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB, are found to be 8- to 30-fold less sensitive to MK-2461 than c-Met. [1] in vivo: MK-2461 inhibits c-Met signaling and tumor growth in tumor xenograft models in mice.[1]

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (62.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0180 mL 10.0898 mL 20.1796 mL
5 mM 0.4036 mL 2.0180 mL 4.0359 mL
10 mM 0.2018 mL 1.0090 mL 2.0180 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

495.55

Formula

C₂₄H₂₅N₅O₅S

CAS No.

917879-39-1

SMILES

O=S(N(C)C[[email protected]]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O

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Room temperature in continental US; may vary elsewhere

Purity: 99.92%

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Product Name:
MK-2461
Cat. No.:
HY-50703
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MK-2461

Cat. No.: HY-50703