917879-39-1
917879-39-1
Chemical Structure
MK-2461
- CAS No.: 917879-39-1
- Formula:C24H25N5O5S
- Molecular Weight:495.55
InChIKey: JGEBLDKNWBUGRZ-HXUWFJFHSA-N
SMILES: O=S(N(C)C[C@H]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O
Biological Activity: MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM). MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM). MK-2461 can be used for the study of cancer, such as gastric cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MK-2461 | 99.28% | MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM). MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM). MK-2461 can be used for the study of cancer, such as gastric cancer. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.60
HY-13299AMK-8033 hydrochloride -
Similarity Score 0.60
HY-13299MK-8033 -
Similarity Score 0.48
HY-115805YKL-04-085 -
Similarity Score 0.47
HY-180452HAT-IN-10 -
Similarity Score 0.46
HY-171174CDK8-IN-16 -
Similarity Score 0.46
HY-181855PI3K/PIKK-IN-2 -
Similarity Score 0.46
HY-137435Cirtuvivint -
Similarity Score 0.46
HY-208722MAP3K1-IN negative control -
Similarity Score 0.45
HY-178987BJH-86 -
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