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ML329 

製品番号: HY-101464 純度: >98.0%
取扱説明書

ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.

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ML329 構造式

ML329 構造式

CAS 番号 : 19992-50-8

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in DMSO USD 158 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 144 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 252 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 540 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 912 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 1560 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM.

IC50 & Target

IC50: 1.2 μM (TRPM-1)[1]

体外実験

ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression[1].

分子量

328.34

分子式

C₁₆H₁₂N₂O₄S

CAS 番号

19992-50-8

SMILES

O=S(C1=CC=C(NC(C2=O)=CC(C3=C2C=CC=C3)=O)C=C1)(N)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 31 mg/mL (94.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0456 mL 15.2281 mL 30.4562 mL
5 mM 0.6091 mL 3.0456 mL 6.0912 mL
10 mM 0.3046 mL 1.5228 mL 3.0456 mL
*Please refer to the solubility information to select the appropriate solvent.
参考文献
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Keywords:

ML329ML 329ML-329OthersInhibitorinhibitorinhibit

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製品名:
ML329
製品番号:
HY-101464
数量:
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