1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

NMDAR antagonist 1 

Cat. No.: HY-111500
Handling Instructions

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.

For research use only. We do not sell to patients.

NMDAR antagonist 1 Chemical Structure

NMDAR antagonist 1 Chemical Structure

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100 mg USD 3300 Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].

IC50 & Target

NMDAR[1]

In Vitro

NMDAR antagonist 1 (Compound 5q) exhibits excellent neuroprotective activity[1].
NMDAR antagonist 1 can attenuate Ca2+ influx induced by NMDA[1].
NMDAR antagonist 1 can suppress the NR2B up-regulation and increase p-ERK1/2 expression[1].
NMDAR antagonist 1 inhibits SH-SY5Y cells with cell viabilities of 75.8%, 80.0%, 84.4%, and 78.6% at 0.1 µM 1 µM 10 µM 100 µM, respectively[1].

References
Molecular Weight

414.30

Formula

C₂₀H₂₀BrN₃O₂

SMILES

O=C(NCCC1=CC=C(O)C=C1)C2CCC3=NC4=CC=C(Br)C=C4CN32

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
NMDAR antagonist 1
Cat. No.:
HY-111500
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NMDAR antagonist 1

Cat. No.: HY-111500