1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. NMDAR antagonist 1

NMDAR antagonist 1 

Cat. No.: HY-111500
Handling Instructions

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.

For research use only. We do not sell to patients.

NMDAR antagonist 1 Chemical Structure

NMDAR antagonist 1 Chemical Structure

Size Price Stock
5 mg USD 450 Get quote
10 mg USD 750 Get quote
25 mg USD 1500 Get quote
50 mg USD 2100 Get quote
100 mg USD 3300 Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].

IC50 & Target

NMDAR[1]

In Vitro

NMDAR antagonist 1 (Compound 5q) exhibits excellent neuroprotective activity[1].
NMDAR antagonist 1 can attenuate Ca2+ influx induced by NMDA[1].
NMDAR antagonist 1 can suppress the NR2B up-regulation and increase p-ERK1/2 expression[1].
NMDAR antagonist 1 inhibits SH-SY5Y cells with cell viabilities of 75.8%, 80.0%, 84.4%, and 78.6% at 0.1 µM 1 µM 10 µM 100 µM, respectively[1].

Molecular Weight

414.30

Formula

C₂₀H₂₀BrN₃O₂

SMILES

O=C(NCCC1=CC=C(O)C=C1)C2CCC3=NC4=CC=C(Br)C=C4CN32

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.07 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4137 mL 12.0685 mL 24.1371 mL
5 mM 0.4827 mL 2.4137 mL 4.8274 mL
10 mM 0.2414 mL 1.2069 mL 2.4137 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
NMDAR antagonist 1
Cat. No.:
HY-111500
Quantity: