1. Immunology/Inflammation
  2. COX
  3. Nitroflurbiprofen

Nitroflurbiprofen (Synonyms: HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen)

Cat. No.: HY-U00013 Purity: 99.64%
Handling Instructions

Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

For research use only. We do not sell to patients.

Nitroflurbiprofen Chemical Structure

Nitroflurbiprofen Chemical Structure

CAS No. : 158836-71-6

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Description

Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

IC50 & Target

COX

 

In Vivo

In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].

Molecular Weight

361.36

Formula

C₁₉H₂₀FNO₅

CAS No.

158836-71-6

SMILES

O=C(OCCCCO[N+]([O-])=O)C(C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Animal Administration
[1]

Rats[1]
Male Wistar rats, weighing 200-250 g, are used. After 18 weeks of TAA administration, cirrhotic rats are equally (n=8/group) and randomly allocated to one of the following groups: intraperitoneal injection, 24 hours and 1 hour prior to the measurements, with Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle (250 μL DMSO:250 μL isotonic saline). The used dose is based on a dose-finding study (n=5 per condition). The concentrations of Nitroflurbiprofen (15 mg/kg) and Flurbiprofen (7.5 mg/kg, equimolar concentration to Nitroflurbiprofen Flurbiprofen) are started, then are increased the dose to Nitroflurbiprofen 22.5 mg/kg and Flurbiprofen 15 mg/kg, and, finally, Nitroflurbiprofen 45 mg/kg and Flurbiprofen 30 mg/kg. The last dose regimen has the most profound hemodynamic effects.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.64%

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Keywords:

NitroflurbiprofenHCT 1206NO-flurbiprofenNitroxybutyl flurbiprofenHCT1206HCT-1206COXCyclooxygenaseInhibitorinhibitorinhibit

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Nitroflurbiprofen
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