1. Protein Tyrosine Kinase/RTK
  2. RET
  3. Selpercatinib

Selpercatinib 

Cat. No.: HY-114370 Purity: 99.23%
Handling Instructions

Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively. Antineoplastic activity.

For research use only. We do not sell to patients.

Selpercatinib Chemical Structure

Selpercatinib Chemical Structure

CAS No. : 2152628-33-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 289 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Purity & Documentation

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Description

Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2].

IC50 & Target

IC50: 14.0 nM (RETWT), 24.1 nM (RETV804M), 530.7 nM (RETG810R)[1]

Molecular Weight

525.60

Formula

C₂₉H₃₁N₇O₃

CAS No.

2152628-33-4

SMILES

N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (15.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9026 mL 9.5129 mL 19.0259 mL
5 mM 0.3805 mL 1.9026 mL 3.8052 mL
10 mM 0.1903 mL 0.9513 mL 1.9026 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.23%

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Product Name:
Selpercatinib
Cat. No.:
HY-114370
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