1. GPCR/G Protein
  2. LPL Receptor

S1P1 Agonist III 

Cat. No.: HY-12835
Handling Instructions

S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.

For research use only. We do not sell to patients.
S1P1 Agonist III Chemical Structure

S1P1 Agonist III Chemical Structure

CAS No. : 1324003-64-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 238 In-stock
10 mg USD 216 In-stock
50 mg USD 864 Get quote
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. IC50 value: 18 nM(EC50) [1] Target: S1P1 agonist When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4075 mL 12.0375 mL 24.0749 mL
5 mM 0.4815 mL 2.4075 mL 4.8150 mL
10 mM 0.2407 mL 1.2037 mL 2.4075 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

415.37

Formula

C₂₁H₁₆F₃N₃O₃

CAS No.

1324003-64-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
S1P1 Agonist III
Cat. No.:
HY-12835
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