1. Signaling Pathways
  2. Anti-infection
  3. CMV

CMV

Cytomegalovirus

Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the ubiquitous family of herpesviruses. Cytomegaloviruses escape immunological clearance and persist throughout life in the infected host. Yet, the stability of the balance of this virus-host interaction is dependent upon the state of the cellular immune response, and usually requires the function of specific CD8 T lymphocytes.

Human cytomegalovirus is a member of the viral family known as herpesviruses, Herpesviridae, or human herpesvirus-5 (HHV-5). Human cytomegalovirus infections commonly are associated with the salivary glands. CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer.

CMV Related Products (106):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W270868
    CBMicro_010679
    Inhibitor
    CBMicro_010679 (Compound 5) is a non-nucleoside anti-herpesvirus agent. CBMicro_010679 has broad-spectrum herpes antiviral activities against CMV and VZV with IC50s of 6.6 and 4.8 μM, respectively. CBMicro_010679 can be used for herpesvirus infections research.
    CBMicro_010679
  • HY-W150426
    Naphthol AS-BS
    Inhibitor
    Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC50 of 12 μM. Naphthol AS-BS can be used for the research of infection.
    Naphthol AS-BS
  • HY-A0032
    Valganciclovir
    Inhibitor
    Valganciclovir is an orally active antiviral agent. Valganciclovir can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir can be used for the research of Cytomegalovirus.
    Valganciclovir
  • HY-185150
    PMEG
    Inhibitor
    PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma[1][2].
    PMEG
  • HY-13578S
    Brivudine-13C,15N2
    Inhibitor
    Brivudine-13C, 15N2 (Bromovinyldeoxyuridine-13C, 15N2) is 13C and 15N labeled Brivudine. Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
    Brivudine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-13578R
    Brivudine (Standard)
    Inhibitor
    Brivudine (Standard) is the analytical standard of Brivudine. This product is intended for research and analytical applications. Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
    Brivudine (Standard)