2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis CMV
  4. PMEG

PMEG  (Synonyms: 9-(2-Phosphonylmethoxy)ethylguanine)

Cat. No.: HY-185150
Handling Instructions Technical Support

PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma[1][2].

For research use only. We do not sell to patients.

PMEG

PMEG Chemical Structure

CAS No. : 114088-58-3

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PMEG Related Antibodies

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Description

PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma[1][2].

IC50 & Target

DNA Polymerase

 

In Vivo

Rabacfosadine (GS-9219) (HY-13640) (0.20–0.82 mg/kg; intravenous infusion over 30 minutes) accumulates extensively in lymphoid cells as PMEG and induces remission in pet dogs with spontaneous non-Hodgkin lymphoma (remission rate of 79%)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

289.19

Formula

C8H12N5O5P
CAS No.
SMILES

O=C1N=C(NC2=C1N=CN2CCOCP(O)(O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PMEG Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PMEG114088-58-39-(2-Phosphonylmethoxy)ethylguanineDNA/RNA SynthesisCMVCytomegaloviruslymphoid cellsDNA synthesisdividing cellsleukemiarodent modelsclient-owned pet dogscytotoxicityanticancer agentεhigh-proliferation lymphoid malignanciesnon-hodgkin's lymphomaspontaneous non-Hodgkin's lymphomanuclear DNA polymerases αδDNA chain terminationmelanomaInhibitorinhibitorinhibit

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