GnRH Receptor
Gonadotropin releasing hormone receptor; GNRHR
The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.
Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.
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GnRH Receptor Related Products (161)
Related Products (161)
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Antibodies (3)
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Metallibure
0 ImagesMethallibure (ICI 33828) is a dithiocarbamoylhydrazine derivative and gonadotropic function blocker. Methallibure can block the action of pituitary gonadotropins in teleost fishes and inhibit germ cell maturation. Methallibure does not affect the histological structure of the thyroid gland but reduces the nuclear volume of thyroid epithelial cells. Methallibure can be used in the research of endocrine diseases.
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(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH
0 ImagesCat. No.: HY-P4688CAS No.: 1926163-83-8(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone.
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(Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken)
0 ImagesCat. No.: HY-P3583CAS No.: 145940-57-4Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) is an active petide. (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) can be used for the research of various biochemical studies.
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Glp-His-Pro-Gly-NH2
0 ImagesCat. No.: HY-P3975CAS No.: 41880-59-5Synonyms: pGlu-His-Pro-Gly-NH2Glp-His-Pro-Gly-NH2 (pGlu-His-Pro-Gly-NH2) is a peptide containing 4 amino acids. Glp-His-Pro-Gly-NH2 stimulates gonadotrophin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) release.
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LHRH (1-5) free acid
0 ImagesCat. No.: HY-P4739CAS No.: 52434-75-0LHRH (1-5) (free acid) is a polypeptide generated by the cleavage of LHRH at the Tyr55-Gly66 site. LHRH (1-5) (free acid) is converted into LHRH (1-3) and LHRH (4-5) fragments under the catalysis of Angiotensin-converting enzyme (HY-P2983).
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Human follicular gonadotropin releasing peptide
0 ImagesCat. No.: HY-P3084CAS No.: 107873-08-5Synonyms: hF-GRPHuman follicular gonadotropin releasing peptide (hF-GRP) is a hormone peptide. Human follicular gonadotropin releasing peptide can stimulate pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in vitro.
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ORG 30276
0 ImagesCat. No.: HY-P2446CAS No.: 83539-08-6Synonyms: APTAA-LHRHORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
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Elagolix-13C,d3 sodium
0 ImagesCat. No.: HY-14369SSynonyms: NBI-56418-13C,d3 sodiumElagolix-13C,d3 (sodium) is the 13C- and deuterium labeled Elagolix sodium. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
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[Ala6]-LHRH
![[Ala6]-LHRH](https://file.medchemexpress.com/product_pic/hy-p2419.gif "Click to View [Ala6]-LHRH Product Detail")
0 ImagesCat. No.: HY-P2419CAS No.: 51278-35-4[Ala6]-LHRH is a synthetic luteinizing hormone-releasing hormone agonist, demonstrating effective stimulation of pituitary luteinizing hormone secretion. [Ala6]-LHRH enhances reproductive hormone regulation, contributing to fertility treatments. [Ala6]-LHRH plays a crucial role in managing conditions related to hormone imbalances.
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Degarelix-d7
0 ImagesCat. No.: HY-16168ASSynonyms: FE 200486-d7 free baseDegarelix-d7 (FE 200486-d7 free base) is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.
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Histrelin
0 ImagesCat. No.: HY-P0056CAS No.: 76712-82-8Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.
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GnRH Associated Peptide (1-24), human
0 ImagesCat. No.: HY-P3606CAS No.: 148943-65-1Synonyms: GAP (1-24), humanGnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.
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(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
0 ImagesCat. No.: HY-P4568CAS No.: 1926163-39-4(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
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Elagolix
0 ImagesCat. No.: HY-115633CAS No.: 2323071-30-1Elagolix is an orally active, highly effective, selective and non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis.
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LH-RH (4-10)
0 ImagesCat. No.: HY-P3675CAS No.: 51776-33-1LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes.
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[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
![[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH](https://file.medchemexpress.com/product_pic/hy-p3671.gif "Click to View [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH Product Detail")
0 ImagesCat. No.: HY-P3671CAS No.: 68059-94-9[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist.
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(Ser(tBu)6,Azagly10)-LHRH
0 ImagesCat. No.: HY-P4693CAS No.: 184686-52-0(Ser(tBu)6,Azagly10)-LHRH is a potent aza-GLY analog.
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Goserelin-d7
0 ImagesCat. No.: HY-13673S1Synonyms: ICI 118630-d7
