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Referencia número: HY-P10378

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GPR10 agonist 1

GPR10 agonist 1 (compound 18-S4) is a potent GPR10 agonist with EC₅₀ values of 80, 7.8 nM in the presence (10%) or absence (0%) of FBS, respectively. GPR10 agonist 1 has the potential for the research of chronic obesity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₀₀H₃₂₄N₅₈O₅₇S₂
Peso molecular:4517.20

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

GPR10 agonist 1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vivo

GPR10 agonist 1 (compound 18-S4) (0.5, 5 mg/kg; s.c.; daily for 12 day) decreases diet-induced obesity (DIO) mouse body weight^[1].
Pharmacokinetic Parameters (1 mg/kg; s.c.; 7-9 weeks, male C57 mice)^[1].

t_1/2(h)	C_max(ng/mL)	AUC_last(ng·h/mL)	AUC_∞(ng·h/mL)	AUC_{0-24 h}(ng·h/mL)
7.81	1670	17700	17900	15500

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

24 weeks male mice (a diet-induced obesity (DIO) mouse model)^[1]
Dosage:

0.5, 5 mg/kg
Administration:

S.c.; daily for 12 daily
Result:

Significantly decreased the body weight at 0.5 mg/kg and 5 mg/kg daily injection gave similar efficacy to the 0.5 mg/kg dose.

Chemical Information

Peso molecular 4517.20
Fòrmula C₂₀₀H₃₂₄N₅₈O₅₇S₂
Sequence

Ser-Arg-Ala-His-Gln-Cys-Ser-{Nle}-Glu-Thr-Arg-Thr-Cys-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Thr-Gly-{hArg}-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2 (Disulfide bridge: Cys6-Cys13; multiple ethylene glycol-fatty acid; hArg=Homoarginine)
Sequence Shortening

SRAHQCS-{Nle}-ETRTCDINPAWYTG-{hArg}-GIRPVGRF-NH2 (Disulfide bridge: Cys6-Cys13; multiple ethylene glycol-fatty acid; hArg=Homoarginine)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pflimlin E, et al. Design of a Long-Acting and Selective MEG-Fatty Acid Stapled Prolactin-Releasing Peptide Analog. ACS Med Chem Lett. 2019 Jul 5;10(8):1166-1172. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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