926-93-2
Chemical Structure
Metallibure
Synonym(s): ICI 33828; Methallibure
- CAS No.: 926-93-2
- Formula:C7H14N4S2
- Molecular Weight:218.34
IUPAC Name: N1-(but-3-en-2-yl)-N2-methylhydrazine-1,2-bis(carbothioamide)
InChIKey: CGFFKDRVHZIQHL-UHFFFAOYSA-N
SMILES: CNC(NNC(NC(C=C)C)=S)=S
Biological Activity: Methallibure (ICI 33828) is a dithiocarbamoylhydrazine derivative and gonadotropic function blocker. Methallibure can block the action of pituitary gonadotropins in teleost fishes and inhibit germ cell maturation. Methallibure does not affect the histological structure of the thyroid gland but reduces the nuclear volume of thyroid epithelial cells. Methallibure can be used in the research of endocrine diseases[1][2].
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Metallibure | Methallibure (ICI 33828) is a dithiocarbamoylhydrazine derivative and gonadotropic function blocker. Methallibure can block the action of pituitary gonadotropins in teleost fishes and inhibit germ cell maturation. Methallibure does not affect the histological structure of the thyroid gland but reduces the nuclear volume of thyroid epithelial cells. Methallibure can be used in the research of endocrine diseases. | |||||||||||||||||||||
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- [1]. Hoar W S, et al. Inhibition of the pituitary gonadotropic activity of fishes by a dithiocarbamoylhydrazine derivative (ICI 33,828). General and Comparative Endocrinology, 1967, 8(1): 101-109.
- [2]. Löw O, et al. Morphometrie an indokrinen Organen. II. Karyometrie an Schilddrüsen von Hunden und Schweinen nach Applikation von TURISYNCHRON und SUISYNCHRON [Morphometry of endocrine organs. 2. Karyometry of dog and swine thyroid glands following administration of TURISYNCHRON and SUISYNCHRON]. Arch Exp Veterinarmed. 1974;28(5):725-30. German. [Content Brief]
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