Progesterone Receptor
NR3C3
Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.
Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.
In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).
All Product Categories
-
Progesterone Receptor Inhibitors
(11)
View all products
-
Progesterone Receptor Agonists
(76)
View all products
-
Progesterone Receptor Antagonists
(24)
View all products
-
Progesterone Receptor Activators
(10)
View all products
-
Progesterone Receptor Modulators
(10)
View all products
-
Progesterone Receptor Ligands
(5)
View all products
-
Progesterone Receptor Proteins
(1)
View all products
-
Progesterone Receptor Related Products (161)
Related Products (161)
-
Recombinant Proteins (1)
-
Antibodies (2)
- 1
- 2
-
Mifepristone
0 ImagesSynonyms: RU486; RU 38486Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
-
CP8754
0 ImagesCat. No.: HY-119080CAS No.: 532435-68-0CP8754 is an orally active, selective human progesterone receptor (hPR) antagonist that blocks progesterone-mediated signaling pathways. CP8754 competitively inhibits the binding of [3H]-progesterone to hPR. And in vitro, CP8754 inhibits progesterone-dependent exogenous luciferase and endogenous alkaline phosphatase expression; while in vivo, CP8754 inhibits rabbit endometrial transformation. CP8754 does not significantly bind to human glucocorticoid receptors (hGR), estrogen receptors (hER), or rat androgen receptors (rAR). CP8754 can be used in the study of progesterone-related diseases such as breast cancer, endometriosis, uterine fibroids, and meningioma, as well as hormone-dependent tumors.
-
Ulipristal acetate
0 ImagesSynonyms: CDB-2914Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.
-
PF-02413873
0 ImagesSynonyms: PF-2413873PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.
-
Mifepristone (Standard)
0 ImagesSynonyms: RU486 (Standard); RU 38486 (Standard)Mifepristone (Standard) is the analytical standard of Mifepristone. This product is intended for research and analytical applications. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
-
PR antagonist 1
0 ImagesPR antagonist 1 (compound 8) is a selective progesterone receptor (PR) antagonist, and can be used for the research of a variety of progesterone-related diseases and disorders such as endometriosis and uterine fibroids.
-
Mifepristone-d3
0 ImagesCat. No.: HY-13683SSynonyms: RU486-d3; RU 38486-d3Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
-
Mifepristone-d6
0 ImagesSynonyms: RU486-d6; RU 38486-d6Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
-
PF-3882845
0 ImagesPF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM.
-
Mifepristone-13C,d3
0 ImagesCat. No.: HY-13683S1Synonyms: RU486-13C,d3; RU 38486-13C,d3Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
WAY-255348
0 ImagesCat. No.: HY-12073CAS No.: 872141-23-6W-255348 is an effective non-steroidal progesterone receptor (PR) antagonist that acquires antagonist activity by binding to and subsequently blocking progesterone induced nuclear accumulation, phosphorylation, and PR promoter interactions. WAY-255348 can be used in the research of reproductive disorders or PR-positive breast cancer.
-
JNJ-1250132
0 ImagesCat. No.: HY-123163CAS No.: 240805-96-3Synonyms: RWJ-66826; RTI-6617-003JNJ-1250132 (RWJ-66826) is an orally active and potent steroidal progesterone receptor (PR) antagonist, with an IC50 of 1.3 nM. JNJ-1250132 inhibits binding of the receptor to DNA in vitro. JNJ-1250132 is a potent competitive inhibitor of binding to the human glucocorticoid receptor (GR) (IC50=0.50 nM) and the rat androgen receptor (AR) (IC50=5.6 nM), and was a weak inhibitor of binding to human Estrogen receptor (ER) (IC50 >3000 nM).
-
Ulipristal acetate-d6
0 ImagesCat. No.: HY-16508SCAS No.: 1621894-64-1Synonyms: CDB-2914-d6Ulipristal acetate-d6 is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.
-
Onapristone
0 ImagesCat. No.: HY-106389CAS No.: 96346-61-1Synonyms: ZK 98299Onapristone is a progesterone receptor antagonist, with Kds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity.
-
Cymipristone
0 ImagesCat. No.: HY-119482CAS No.: 329971-40-6Cymipristone (ZXH-951), a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.
-
ZK112993
0 ImagesCat. No.: HY-113889CAS No.: 105114-63-4ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice.
-
Lonaprisan
0 ImagesCat. No.: HY-16290CAS No.: 211254-73-8Synonyms: ZK 230211; BAY86 5044Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect.
-
PF-02413873 (Standard)
0 ImagesCat. No.: HY-11028RCAS No.: 936345-35-6Synonyms: PF-2413873 (Standard)PF-02413873 (Standard) is the analytical standard of PF-02413873 (HY-11028). This product is intended for research and analytical applications. PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.
-
PF 02367982
0 ImagesCat. No.: HY-14465CAS No.: 913344-84-0PF 02367982 is a potent and select progesterone receptor (PR) antagonist with an IC50 value of 47.3 nM. PF 02367982 has oral activity.
-
Telapristone
0 ImagesCat. No.: HY-14901CAS No.: 198414-30-1Telapristone is a Progesterone antagonist. Telapristone can be used in the study of uterine fibroids and endometriosis.
- 1
- 2
