240805-96-3
Chemical Structure
JNJ-1250132
Synonym(s): RWJ-66826; RTI-6617-003
- CAS No.: 240805-96-3
- Formula:C33H41NO4
- Molecular Weight:515.68
IUPAC Name: (8S,11R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-11-(4-(piperidin-1-yl)phenyl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
InChIKey: AFUBKIQQSUBSGF-LNAXGRFASA-N
SMILES: CC([C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N6CCCCC6)C=C5)C[C@]12C)=O)=O
Biological Activity: JNJ-1250132 (RWJ-66826) is an orally active and potent steroidal progesterone receptor (PR) antagonist, with an IC50 of 1.3 nM. JNJ-1250132 inhibits binding of the receptor to DNA in vitro. JNJ-1250132 is a potent competitive inhibitor of binding to the human glucocorticoid receptor (GR) (IC50=0.50 nM) and the rat androgen receptor (AR) (IC50=5.6 nM), and was a weak inhibitor of binding to human Estrogen receptor (ER) (IC50 >3000 nM)[1].
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JNJ-1250132 | JNJ-1250132 (RWJ-66826) is an orally active and potent steroidal progesterone receptor (PR) antagonist, with an IC50 of 1.3 nM. JNJ-1250132 inhibits binding of the receptor to DNA in vitro. JNJ-1250132 is a potent competitive inhibitor of binding to the human glucocorticoid receptor (GR) (IC50=0.50 nM) and the rat androgen receptor (AR) (IC50=5.6 nM), and was a weak inhibitor of binding to human Estrogen receptor (ER) (IC50 >3000 nM). | |||||||||||||||||||||
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Keywords
