Proton Pump
Proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on theQ cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. It is an active pump, that generates a protonconcentration gradient across the inner mitochondrial membrane, because there are more protons outside the matrix than inside. The difference in pH and electric charge (ignoring differences inbuffer capacity) creates an electrochemical potential difference that works similar to that of a battery or energy storing unit for the cell. The process could also be seen as analogous to cycling uphill or charging a battery for later use, as it produces potential energy. The proton pump does not create energy, but forms a gradient that stores energy for later use.
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Proton Pump Related Products (183)
Related Products (183)
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Antibodies (1)
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Ilaprazole-d3
0 ImagesCat. No.: HY-101664SCAS No.: 1070969-17-3Synonyms: IY-81149-d3
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HV1-IN-1 hydrochloride
0 ImagesCat. No.: HY-163696ACAS No.: 1609461-57-5HV1-IN-1 hydrochloride is an inhibitor of the human voltage-gated proton channel (hHV1). HV1-IN-1 hydrochloride works by binding to the VSD of the HV1 channel. The VSD is a component of the HV1 channel that is responsible for detecting changes in membrane potential and triggering the opening of the channel. HV1-IN-1 hydrochloride can be used in the study of cancer, neuroinflammation and immune response.
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Tegoprazan-d6
0 ImagesCat. No.: HY-17623SSynonyms: CJ-12420-d6; RQ-00000004-d6Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases.
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Padoprazanum fumarate
0 ImagesCat. No.: HY-400540ACAS No.: 2938973-98-7Padoprazanum (Padoprazan) fumarate is a Proton Pump inhibitor.
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FR-167356
0 ImagesCat. No.: HY-123370CAS No.: 174185-16-1FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss.
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TS 155-2
0 ImagesCat. No.: HY-123095CAS No.: 1314486-37-7Synonyms: JBIR 100TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis.
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Tiludronate-d5 sodium
0 ImagesCat. No.: HY-A0213ASSynonyms: Tiludronic acid-d5 sodiumTiludronate-d5 (sodium)mis the deuterium labeled Tiludronate disodium. Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
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Pantoprazole sodium (Standard)
0 ImagesCat. No.: HY-17507ARCAS No.: 138786-67-1Synonyms: BY1023 sodium (Standard); SKF96022 sodium (Standard)Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142).
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Lansoprazole sulfide-d4
0 ImagesSynonyms: AG-1777-d4Lansoprazole sulfide-d4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.
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WY-47766
0 ImagesCat. No.: HY-105220CAS No.: 134217-27-9Synonyms: OST-766WY-47766(OST-766) is aproton pumpinhibitor.
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Pantoprazole sodium hydrate (Standard)
0 ImagesSynonyms: BY1023 sodium hydrate (Standard); SKF96022 sodium hydrate (Standard)Pantoprazole (sodium hydrate) (Standard) is the analytical standard of Pantoprazole (sodium hydrate). This product is intended for research and analytical applications. Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142).
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Concanamycin A (purity≥70%)
0 ImagesCat. No.: HY-N1724ACAS No.: 80890-47-7Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research-.
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Lansoprazole sulfone (Standard)
0 ImagesCat. No.: HY-W008614RCAS No.: 131926-99-3Synonyms: AG-1813 (Standard)Lansoprazole sulfone (AG-1813) (Standard) is the analytical standard of Lansoprazole sulfone (HY-W008614). This product is intended for research and analytical applications. Lansoprazole sulfone, Lansoprazole (HY-13662) metabolite, is a H+, K+-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
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Esomeprazole sodium (Standard)
0 ImagesSynonyms: (S)-Omeprazole sodium (Standard); (-)-Omeprazole sodium (Standard)Esomeprazole (sodium) (Standard) is the analytical standard of Esomeprazole (sodium). This product is intended for research and analytical applications. Esomeprazole sodium ((S)-Omeprazole sodium) is a potent and orally active proton pump inhibitor. Esomeprazole reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.
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CS-526
0 ImagesCat. No.: HY-100413CAS No.: 313272-12-7CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H+,K+-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease.
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Rabeprazole sodium (Standard)
0 ImagesCat. No.: HY-B0656ARCAS No.: 117976-90-6Synonyms: LY307640 sodium (Standard)Rabeprazole (sodium) (Standard) is the analytical standard of Rabeprazole (sodium). This product is intended for research and analytical applications. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.
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Rabeprazole-d3 sodium
0 ImagesCat. No.: HY-B0656AS1CAS No.: 1216494-11-9Synonyms: LY307640-d3 sodiumRabeprazole-d3 sodium the deuterium labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an b>IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.
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Esomeprazole-d3 sodium
0 ImagesCat. No.: HY-17021SSynonyms: (S)-Omeprazole-d3 sodium; (-)-Omeprazole-d3 sodiumEsomeprazole-d3 (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.
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Concanamycin D
0 ImagesCat. No.: HY-N14423CAS No.: 144450-34-0Concanamycin D is a lysosomal acidification inhibitor with an IC50 value of 0.085 nM.
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(R)-(+)-Pantoprazole sodium
0 ImagesCat. No.: HY-W703279CAS No.: 160098-11-3Synonyms: (R)-(+)-BY1023 sodium; (R)-(+)-SKF96022 sodium(R)-(+)-Pantoprazole ((R)-(+)-BY1023) sodium is a proton pump inhibitor that can be used for the study of gastroesophageal reflux disease.
