1. CS-526

CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H+,K+-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease.

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CS-526 Chemical Structure

CS-526 Chemical Structure

CAS No. : 313272-12-7

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Description

CS-526 is a potent, selective, reversible and orally active acid pump antagonist. CS-526 inhibits H+,K+-ATPase activity. CS-526 inhibits gastric acid secretion and prevents esophageal lesions. CS-526 has the potential for the research of gastroesophageal reflux disease[1].

In Vitro

CS-526 (0-100 µM; 60 min) inhibits H+, K+-ATPase and Na+, K+-ATPase activity in a dose-dependent manner with IC50 values of 61 nM, 10.4 µM, respectively[1].
CS-526 competitive binds to K+ binding site of H+, K+-ATPase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) inhibits gastric acid secretion in a dose-dependent manner in pylorus-ligated rats[1].
CS-526 (1, 3, 10, 30 mg/kg; intrapouch; 180 min) dose-dependently inhibits the histamine-induced gastric acid secretion in the Heidenhain pouch dogs[1].
CS-526 (1, 3, 10, 30 mg/kg; intraduodenal or p.o.) prevents esophageal lesions and acute gastric mucosal lesions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pylorus-Ligated Rats[1]
Dosage: 1, 3, 10, 30 mg/kg
Administration: Intraduodenal administration or p.o.
Result: Dose-dependently inhibited gastric acid secretion with ID50 values of 2.8, 0.7 mg/kg for intraduodenal administration and oral administration, respectively.
Animal Model: Reflux Esophagitis Model in Rats[1]
Dosage: 1, 3, 10 mg/kg
Administration: Intraduodenal administration or p.o.
Result: Significantly reduced the lesion scores with ID50 values of 5.4, 1.9 mg/kg for intraduodenal and p.o. respectively.
Molecular Weight

339.41

Formula

C20H22FN3O

CAS No.
SMILES

C[C@@H]1[C@@H](CN2C(C)=C(C)C3=C2C(OCC4=CC=C(F)C=C4)=NN=C3)C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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CS-526
Cat. No.:
HY-100413
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