1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. WHI-P97

WHI-P97 

Cat. No.: HY-11067 Purity: 99.48%
Handling Instructions

WHI-P97 is a rationally designed potent inhibitor of JAK-3.

For research use only. We do not sell to patients.

WHI-P97 Chemical Structure

WHI-P97 Chemical Structure

CAS No. : 211555-05-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 168 In-stock
Estimated Time of Arrival: December 31
2 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 168 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg USD 756 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal. WHI-P97 was very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 microg/kg to 50 mg/kg, and LD(10) was not reached at a 50 mg/kg dose level when administered as a single i. p. or i.v. bolus dose.

IC50 & Target[1]

JAK3

11 μM (IC50)

Molecular Weight

455.10

Formula

C₁₆H₁₃Br₂N₃O₃

CAS No.

211555-05-4

SMILES

BrC1=CC(NC2=NC=NC3=CC(OC)=C(OC)C=C32)=CC(Br)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.88 mg/mL (12.92 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1973 mL 10.9866 mL 21.9732 mL
5 mM 0.4395 mL 2.1973 mL 4.3946 mL
10 mM 0.2197 mL 1.0987 mL 2.1973 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.59 mg/mL (1.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.59 mg/mL (1.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.48%

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Keywords:

WHI-P97JAKJanus kinaseInhibitorinhibitorinhibit

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WHI-P97
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HY-11067
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