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  3. A-317567

A-317567 

Cat. No.: HY-122135 Purity: 99.38%
COA Handling Instructions

A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects.

For research use only. We do not sell to patients.

A-317567 Chemical Structure

A-317567 Chemical Structure

CAS No. : 371217-32-2

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Description

A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects[1][2].

IC50 & Target

IC50: 1.025 μM (Acid-sensing ion channel 3 (ASIC-3))[1]

In Vitro

In acutely dissociated adult rat dorsal root ganglion (DRG) neurons, A-317567 produces concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an IC50 ranging between 2 and 30 μM. A-317567 equipotently blocks the sustained phase of ASIC3-like current, a biphasic current akin to cloned ASIC3, which is predominant in DRG[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A-317567 (1-100 μmol/kg; i.p; once) is fully analgesic effects in the CFA model (ED50 of 17 μmol/kg). There is no significant effect of A-317567 on the withdrawal latency of the contralateral paw under these conditions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (230-350 g) injected with Complete Freund’s Adjuvant- (CFA-) induced thermal hyperalgesia[2].
Dosage: 1-100 μmol/kg
Administration: i.p; once
Result: Showed dose-dependent analgesic effects.
Molecular Weight

397.56

Formula

C27H31N3

CAS No.
SMILES

N=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (314.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5153 mL 12.5767 mL 25.1534 mL
5 mM 0.5031 mL 2.5153 mL 5.0307 mL
10 mM 0.2515 mL 1.2577 mL 2.5153 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.23 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
A-317567
Cat. No.:
HY-122135
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