1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. A-317567

A-317567 

Cat. No.: HY-122135
Handling Instructions

A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects.

For research use only. We do not sell to patients.

A-317567 Chemical Structure

A-317567 Chemical Structure

CAS No. : 371217-32-2

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Description

A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects[1][2].

IC50 & Target

IC50: 1.025 μM (Acid-sensing ion channel 3 (ASIC-3))[1]

In Vitro

The effects of A-317567 on three distinct types of native ASIC currents evoked in acutely dissociated adult rat dorsal root ganglion (DRG) neurons are studied. A-317567 produces concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an IC50 ranging between 2 and 30 μM, depending upon the type of ASIC current activated. A-317567 equipotently blocks the sustained phase of ASIC3-like current, a biphasic current akin to cloned ASIC3, which is predominant in DRG[2].

In Vivo

A-317567 is fully analgesic effects in the CFA model (ED50 of 17 μmol/kg, i.p., adult male Sprague-Dawley rats). There is no significant effect of A-317567 on the withdrawal latency of the contralateral paw under these conditions[2].

Molecular Weight

397.56

Formula

C₂₇H₃₁N₃

CAS No.

371217-32-2

SMILES

N=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

A-317567A317567A 317567Sodium ChannelNa channelsNa+ channelsASIC-3antidepressantantinociceptioncurrentsneuronsCFAInhibitorinhibitorinhibit

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