371217-32-2
371217-32-2
Chemical Structure
A-317567
- CAS No.: 371217-32-2
- Formula:C27H31N3
- Molecular Weight:397.56
IUPAC Name: 6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)cyclopropyl)-2-naphthimidamide
InChIKey: FEPIUXBUJVISNN-UHFFFAOYSA-N
SMILES: N=C(C1=CC=C2C=C(C3C(C4=CC5=C(C=C4)CCN(C)C5C(C)C)C3)C=CC2=C1)N
Biological Activity: A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A-317567 | 99.34% | A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects. | ||||||||||||||||||||
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References
- [1]. Kuduk SD, et al. Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24. [Content Brief]
- [2]. Dubé GR, et al. Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain. 2005 Sep;117(1-2):88-96. [Content Brief]
