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Cat. No.: HY-113905

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ZINC12613047

ZINC12613047 is a selective BChE inhibitor with an IC₅₀ of 0.021 μM against huBChE. ZINC12613047 can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 1069521-64-7
Formula: C₂₉H₃₄N₂O₂
Molecular Weight:442.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC12613047 Chemical Structure

CAS No.: 1069521-64-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

ZINC12613047 is a selective BChE inhibitor with an IC₅₀ of 0.021 μM against huBChE. ZINC12613047 can be used for the research of Alzheimer's disease^[1].

IC₅₀ & Target

^[1]

hBCHE

21 nM (IC₅₀)

AChE

102100 nM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

ZINC12613047 (Compound 1) potently and selectively inhibits recombinant huBChE with an IC₅₀ of 0.021 μM; its eutomer (+)-1 has an inhibition constant (K_i) of 2710 pM against huBChE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1069521-64-7
Molecular Weight 442.60
Formula C₂₉H₃₄N₂O₂
SMILES

O=C(C=1C=CC=2C=CC=CC2C1)N(CCOC)CC3CN(CCC3)C4CC=5C=CC=CC5C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Košak U, et al. The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. Journal of medicinal chemistry. 2018 Jan 11;61(1):119-139. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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