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Art. -Nr.: HY-113905

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ZINC12613047

ZINC12613047 is a selective BChE inhibitor with an IC₅₀ of 0.021 μM against huBChE. ZINC12613047 can be used for the research of Alzheimer's disease.

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CAS. Nr.: 1069521-64-7
Formel: C₂₉H₃₄N₂O₂
Molecular Weight:442.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC12613047 Chemical Structure

CAS. Nr.: 1069521-64-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

ZINC12613047 is a selective BChE inhibitor with an IC₅₀ of 0.021 μM against huBChE. ZINC12613047 can be used for the research of Alzheimer's disease^[1].

IC₅₀ & Target

^[1]

hBCHE

21 nM (IC₅₀)

AChE

102100 nM (IC₅₀)

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

ZINC12613047 (Compound 1) potently and selectively inhibits recombinant huBChE with an IC₅₀ of 0.021 μM; its eutomer (+)-1 has an inhibition constant (K_i) of 2710 pM against huBChE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

CAS. Nr. 1069521-64-7
Molecular Weight 442.60
Formel C₂₉H₃₄N₂O₂
SMILES

O=C(C=1C=CC=2C=CC=CC2C1)N(CCOC)CC3CN(CCC3)C4CC=5C=CC=CC5C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Košak U, et al. The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. Journal of medicinal chemistry. 2018 Jan 11;61(1):119-139. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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ZINC12613047

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ZINC12613047 Related Classifications

HY-113905 Related Classifications

Bioz

Keywords

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