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Cat. No.: HY-149053B

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(R)-OY-101

(R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research.

For research use only. We do not sell to patients.

CAS No.: 23495-82-1
Formula: C₂₇H₃₁NO₄
Molecular Weight:433.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(R)-OY-101 Chemical Structure

CAS No.: 23495-82-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

(R)-OY-101 increases the cytotoxicity of Vincristine (HY-N0488A) on Eca109/VCR cells with an IC₅₀ value of 9.9 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic (PK) parameters of OY-101 in SD Rats^[1]
Notes: (R)-OY-101 is a stereoscopic configuration of OY-101.

Administration manner	T_max (h)	C_max (ng/mL)	λ_z (1/h)	T_1/2 (h)	MRT_0-inf (h)	AUC_0-t (ng /mL•h)	AUC_0-inf (ng /mL•h)	AUMC_0-inf (ng /mL•h²)	V_z/F (L/kg)	Cl/F (L/kg/h)	F (%)
Intravenous injection	0.17±0.12	1573.20±143.97	0.15±0.13	8.43±7.83	2.68±0.47	2688.45±180.10	2742.45±218.99	7391.35±1874.05	12.84±11.33	1.10±0.08
Oral gavage	0.38±0.18	636.55±355.60	0.12±0.08	7.37±4.92	4.89±1.01	2665.45±450.92	2737.40±515.20	131110.55±237.09	111.27±56.82	11.16±2.10	7.65±2.15

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 23495-82-1
Molecular Weight 433.54
Formula C₂₇H₃₁NO₄
SMILES

CN1[C@H](CC2=CC=C(OC)C(OCC3=CC=CC=C3)=C2)C4=C(C=C(OC)C(OC)=C4)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zeng R, et al. Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy. J Med Chem. 2023 Mar 23;66(6):4086-4105. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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