2. Membrane Transporter/Ion Channel Apoptosis
  3. P-glycoprotein Apoptosis
  4. (R)-OY-101

(R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research.

For research use only. We do not sell to patients.

(R)-OY-101 Chemical Structure

(R)-OY-101 Chemical Structure

CAS No. : 23495-82-1

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(R)-OY-101 Related Antibodies

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Description

(R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research[1].

In Vitro

(R)-OY-101 increases the cytotoxicity of Vincristine (HY-N0488A) on Eca109/VCR cells with an IC50 value of 9.9 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-OY-101 Related Antibodies
In Vivo

Pharmacokinetic (PK) parameters of OY-101 in SD Rats[1]
Notes: (R)-OY-101 is a stereoscopic configuration of OY-101.

Administration manner Tmax (h) Cmax (ng/mL) λz (1/h) T1/2 (h) MRT0-inf (h) AUC0-t (ng /mL•h) AUC0-inf (ng /mL•h) AUMC0-inf (ng /mL•h2) Vz/F (L/kg) Cl/F (L/kg/h) F (%)
Intravenous injection 0.17±0.12 1573.20±143.97 0.15±0.13 8.43±7.83 2.68±0.47 2688.45±180.10 2742.45±218.99 7391.35±1874.05 12.84±11.33 1.10±0.08
Oral gavage 0.38±0.18 636.55±355.60 0.12±0.08 7.37±4.92 4.89±1.01 2665.45±450.92 2737.40±515.20 131110.55±237.09 111.27±56.82 11.16±2.10 7.65±2.15

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

433.54

Formula

C27H31NO4
CAS No.
SMILES

CN1[C@H](CC2=CC=C(OC)C(OCC3=CC=CC=C3)=C2)C4=C(C=C(OC)C(OC)=C4)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-OY-101 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-OY-10123495-82-1P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Eca109/VCRVincristineVCRInhibitorinhibitorinhibit

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